This proposal by 18 investigators roughly covers three areas of collaborative vision research. Five investigators will undertake: analysis of the role of enzymes, ions and nucleotides in normal photoreceptor function including transdution, biochmical and immunohistological analysis of the components involved in phagocytic interaction between the retinal pigment epithelium (RPE) and photoreceptors (PR), and determination of structural and biochemical abnormalities in RPE, PR interaction (possibly through extracellular colleen and mucopolysacchrides) in several types of experimental animals whose retina dystrophic diseases mimic human disease states. Seven investigators will utilize anatomical, electrical and behavioral studies to determine the specific neural circuit anatomy, transmitters and interaction that produces particular receptive field characteristics in the retina and in striate visual cortex, the particular areas of visual cortex involved in various kinds of visual performance including visual memory and its transfer between hemispheres, the mechaism of anatomical release from cortical blindness, determination of the specific orthogonal coordinate characteristics of receptive fields in several newly discovered areas of visual cortex, and the role of temporal modulation of stimulus in color perception. Six investigators will determine the neuropeptide innervation of the eye and its anatomical origins, the effect of neuropeptides and oher conditions on aqueous humor secretion and removal, the role of neuropeptides in the retina and its central connections, the role of inflammatory response in the clinical course of immune reaction in the eye, and the mechanisms of vasculr regulation in the retina in normal and in diseased retina of glaucoma and diabetes.
| Dhingra, Anuradha; Bell, Brent A; Peachey, Neal S et al. (2018) Microtubule-Associated Protein 1 Light Chain 3B, (LC3B) Is Necessary to Maintain Lipid-Mediated Homeostasis in the Retinal Pigment Epithelium. Front Cell Neurosci 12:351 |
| Mattar, Marcelo G; Olkkonen, Maria; Epstein, Russell A et al. (2018) Adaptation decorrelates shape representations. Nat Commun 9:3812 |
| Cideciyan, Artur V; Sudharsan, Raghavi; Dufour, Valérie L et al. (2018) Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector. Proc Natl Acad Sci U S A 115:E8547-E8556 |
| Zhang, Harrison G; Ying, Gui-Shuang (2018) Statistical approaches in published ophthalmic clinical science papers: a comparison to statistical practice two decades ago. Br J Ophthalmol 102:1188-1191 |
| Huang, Jing; Huang, Jiayan; Chen, Yong et al. (2018) Evaluation of Approaches to Analyzing Continuous Correlated Eye Data When Sample Size Is Small. Ophthalmic Epidemiol 25:45-54 |
| Gómez, Néstor Más; Lu, Wennan; Lim, Jason C et al. (2018) Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation. FASEB J 32:782-794 |
| Morgan, Jessica I W; Vergilio, Grace K; Hsu, Jessica et al. (2018) The Reliability of Cone Density Measurements in the Presence of Rods. Transl Vis Sci Technol 7:21 |
| Chakraborty, Ranjay; Ostrin, Lisa A; Nickla, Debora L et al. (2018) Circadian rhythms, refractive development, and myopia. Ophthalmic Physiol Opt 38:217-245 |
| Bunya, Vatinee Y; Fernandez, Karen B; Ying, Gui-Shuang et al. (2018) Survey of Ophthalmologists Regarding Practice Patterns for Dry Eye and Sjogren Syndrome. Eye Contact Lens 44 Suppl 2:S196-S201 |
| Govorkova, Maria S; Milman, Tatyana; Ying, Gui-Shuang et al. (2018) Inflammatory Mediators in Xanthelasma Palpebrarum: Histopathologic and Immunohistochemical Study. Ophthalmic Plast Reconstr Surg 34:225-230 |
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