Abstract

The goal of the Imaging and Electrophysiology Core Module (IECM) is to provide shared resources to the investigators of the vision research center (VRC) for imaging and electrophysiological recording. The core instruments of the IECM support imaging (confocal and two-photon) and electrophysiology (patch clamp in vitro, simultaneous with 2P imaging) as well as high density multiunit retinal recording using a multi-electrode array. The IECM also subsidizes the use of two confocal microscopes and a cSLO-OCT system for imaging of retina in vivo in canine. The IECM offers full technical assistance through trained personnel to facilitate use of the instruements. The IECM also provides hub of for collaborative work among members of the VRC by enabling multidisciplinary projects about the normal structure and function of the visual system and its pathological alterations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001583-42
Application #
9129723
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
42
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Uyhazi, Katherine E; Miano, Todd; Pan, Wei et al. (2018) Association of Novel Oral Antithrombotics With the Risk of Intraocular Bleeding. JAMA Ophthalmol 136:122-130
Beckel, Jonathan M; Gómez, Néstor Más; Lu, Wennan et al. (2018) Stimulation of TLR3 triggers release of lysosomal ATP in astrocytes and epithelial cells that requires TRPML1 channels. Sci Rep 8:5726
McDougald, Devin S; Dine, Kimberly E; Zezulin, Alexandra U et al. (2018) SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis. Invest Ophthalmol Vis Sci 59:1212-1220
Massengill, Michael T; Ahmed, Chulbul M; Lewin, Alfred S et al. (2018) Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview. Adv Exp Med Biol 1074:185-191
Lu, Wennan; Gómez, Néstor M; Lim, Jason C et al. (2018) The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration. Front Pharmacol 9:242
Guziewicz, Karina E; Cideciyan, Artur V; Beltran, William A et al. (2018) BEST1 gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure. Proc Natl Acad Sci U S A 115:E2839-E2848
Chen, Xi; Mangalesh, Shwetha; Dandridge, Alexandria et al. (2018) Spectral-Domain OCT Findings of Retinal Vascular-Avascular Junction in Infants with Retinopathy of Prematurity. Ophthalmol Retina 2:963-971
Dhingra, Anuradha; Bell, Brent A; Peachey, Neal S et al. (2018) Microtubule-Associated Protein 1 Light Chain 3B, (LC3B) Is Necessary to Maintain Lipid-Mediated Homeostasis in the Retinal Pigment Epithelium. Front Cell Neurosci 12:351
Mattar, Marcelo G; Olkkonen, Maria; Epstein, Russell A et al. (2018) Adaptation decorrelates shape representations. Nat Commun 9:3812
Cideciyan, Artur V; Sudharsan, Raghavi; Dufour, Valérie L et al. (2018) Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector. Proc Natl Acad Sci U S A 115:E8547-E8556

Showing the most recent 10 out of 349 publications