The VRC Biostatistics Core Module (BCM) supports consultation and collaboration in biostatistics and epidemiology to Penn vision scientists. Biostatisticians and data management experts provide advice on study design, sample size/power determination, data management, data analysis, data interpretation, and data presentation. They are also active participants in the development and writing of grant applications and manuscripts. In addition to their methodological and technical expertise, BCM personnel are very knowledgeable about ocular conditions (age-related macular degeneration, glaucoma, myopia, retinopathy of prematurity, etc.) under study by the Penn vision community, about the commonly used measures that are unique to vision research (visual acuity, refractive error, visual field indices, etc) ), about parameters derived from ocular images (retinal thickness from OCT, retinal vessel width and tortuosity from Retcam images, etc.) and the specialized statistical analysis techniques required for many experimental designs used in vision research (correlated data techniques to handle appropriately data from two eyes of the same subject). An additional objective, introduced with this renewal, is to provide bioinformatics support to access and analyze data from the recently acquired OptumInsight healthcare database.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001583-44
Application #
9549056
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
44
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Bunya, Vatinee Y; Fernandez, Karen B; Ying, Gui-Shuang et al. (2018) Survey of Ophthalmologists Regarding Practice Patterns for Dry Eye and Sjogren Syndrome. Eye Contact Lens 44 Suppl 2:S196-S201
Govorkova, Maria S; Milman, Tatyana; Ying, Gui-Shuang et al. (2018) Inflammatory Mediators in Xanthelasma Palpebrarum: Histopathologic and Immunohistochemical Study. Ophthalmic Plast Reconstr Surg 34:225-230
Collins, David W; Gudiseva, Harini V; Chavali, Venkata R M et al. (2018) The MT-CO1 V83I Polymorphism is a Risk Factor for Primary Open-Angle Glaucoma in African American Men. Invest Ophthalmol Vis Sci 59:1751-1759
Radonjic, Ana; Ding, Xiaomao; Krieger, Avery et al. (2018) Illumination discrimination in the absence of a fixed surface-reflectance layout. J Vis 18:11
Song, Ji Yun; Aravand, Puya; Nikonov, Sergei et al. (2018) Amelioration of Neurosensory Structure and Function in Animal and Cellular Models of a Congenital Blindness. Mol Ther 26:1581-1593
Dedania, Vaidehi S; Zacks, David N; Pan, Wei et al. (2018) TESTOSTERONE SUPPLEMENTATION AND RETINAL VASCULAR DISEASE. Retina 38:2247-2252
Ying, Gui-Shuang; Maguire, Maureen G; Glynn, Robert et al. (2018) Tutorial on Biostatistics: Statistical Analysis for Correlated Binary Eye Data. Ophthalmic Epidemiol 25:1-12
Tuten, William S; Cooper, Robert F; Tiruveedhula, Pavan et al. (2018) Spatial summation in the human fovea: Do normal optical aberrations and fixational eye movements have an effect? J Vis 18:6
Sudharsan, Raghavi; Elliott, Michael H; Dolgova, Natalia et al. (2018) Photoreceptor Outer Segment Isolation from a Single Canine Retina for RPE Phagocytosis Assay. Adv Exp Med Biol 1074:593-601
Cooper, Robert F; Tuten, William S; Dubra, Alfredo et al. (2018) Erratum: Non-invasive assessment of human cone photoreceptor function: erratum. Biomed Opt Express 9:1842

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