Abstract

The Noninvasive Assessment of Visual Function Core Module (NACM) has provides resources for the assessment of visual function in laboratory animals. These services are particularly useful in assessing the effects of retinal disease and of therapies that target such disease. The module designs custom testing protocols that are effective for specific research projects, maintains and consolidates equipment for its most effective use by VRC investigators, promotes collaboration and technique sharing across VRC labs, designs and builds (in cooperation with the Instrumentation Core Module) new experimental setups if no adequate commercial equipment is available, trains lab personnel, develops custom software for advanced data processing (in collaboration with the Image Analysis Core Module), consults on data processing, paper and grant preparation, and responses to reviewers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001583-45
Application #
9769744
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
45
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Massengill, Michael T; Ahmed, Chulbul M; Lewin, Alfred S et al. (2018) Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview. Adv Exp Med Biol 1074:185-191
Lu, Wennan; Gómez, Néstor M; Lim, Jason C et al. (2018) The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration. Front Pharmacol 9:242
Guziewicz, Karina E; Cideciyan, Artur V; Beltran, William A et al. (2018) BEST1 gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure. Proc Natl Acad Sci U S A 115:E2839-E2848
Chen, Xi; Mangalesh, Shwetha; Dandridge, Alexandria et al. (2018) Spectral-Domain OCT Findings of Retinal Vascular-Avascular Junction in Infants with Retinopathy of Prematurity. Ophthalmol Retina 2:963-971
Dhingra, Anuradha; Bell, Brent A; Peachey, Neal S et al. (2018) Microtubule-Associated Protein 1 Light Chain 3B, (LC3B) Is Necessary to Maintain Lipid-Mediated Homeostasis in the Retinal Pigment Epithelium. Front Cell Neurosci 12:351
Mattar, Marcelo G; Olkkonen, Maria; Epstein, Russell A et al. (2018) Adaptation decorrelates shape representations. Nat Commun 9:3812
Cideciyan, Artur V; Sudharsan, Raghavi; Dufour, Valérie L et al. (2018) Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector. Proc Natl Acad Sci U S A 115:E8547-E8556
Zhang, Harrison G; Ying, Gui-Shuang (2018) Statistical approaches in published ophthalmic clinical science papers: a comparison to statistical practice two decades ago. Br J Ophthalmol 102:1188-1191
Huang, Jing; Huang, Jiayan; Chen, Yong et al. (2018) Evaluation of Approaches to Analyzing Continuous Correlated Eye Data When Sample Size Is Small. Ophthalmic Epidemiol 25:45-54
Gómez, Néstor Más; Lu, Wennan; Lim, Jason C et al. (2018) Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation. FASEB J 32:782-794

Showing the most recent 10 out of 349 publications