Abstract

The long-term objectives of this project are to conduct clinial studies which will provide new information for understanding, prevention, and management of disorders of the visual system. The first specific aim is to establish a Clinical Reserach CORE Module that will include a biostatistician, clinical coordinator, and computer. This new module will enhance existing and new clinical research projects by providing epidemiologic and biostatistical methodology necessary for conduct of prospective clinical trials, using state-of-the-art data analysis. Examples of projects include: Japanese- American community diabetes study, Yakima diabetic eye screening project, optic neuritis treatment trial, effect of somatostatin analogs on diabetic retinopathy, analysis of dissemination of new knowledge obtained from clinical trials, evaluation of automated perimetry software, evaluation of infant vision testing cards, treatment of Graves' ophthalmopathy, use of intraocular lenses in diabetic patients, clinical pathologic study of eyes from Alzheimer's patients, genetic analysis of ocular coloboma, and application of gene probes for retinal proteins to DNA from patients with inherited retinal dystrophies, including retinitis pigmentosa.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001730-14
Application #
3102431
Study Section
(SRC)
Project Start
1976-06-01
Project End
1991-05-31
Budget Start
1989-06-01
Budget End
1990-05-31
Support Year
14
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Du, Jianhai; An, Jie; Linton, Jonathan D et al. (2018) How Excessive cGMP Impacts Metabolic Proteins in Retinas at the Onset of Degeneration. Adv Exp Med Biol 1074:289-295
Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257
Schmidt, Brian P; Sabesan, Ramkumar; Tuten, William S et al. (2018) Sensations from a single M-cone depend on the activity of surrounding S-cones. Sci Rep 8:8561
Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540
Leonard, Andrea; Bertero, Alessandro; Powers, Joseph D et al. (2018) Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues. J Mol Cell Cardiol 118:147-158
Arbach, Hannah E; Harland-Dunaway, Marcus; Chang, Jessica K et al. (2018) Extreme nuclear branching in healthy epidermal cells of the Xenopus tail fin. J Cell Sci 131:
Pallus, Adam C; Walton, Mark M G; Mustari, Michael J (2018) Activity of near response cells during disconjugate saccades in strabismic monkeys. J Neurophysiol :
Kojima, Yoshiko; Soetedjo, Robijanto (2018) Elimination of the error signal in the superior colliculus impairs saccade motor learning. Proc Natl Acad Sci U S A 115:E8987-E8995
Manookin, Michael B; Patterson, Sara S; Linehan, Conor M (2018) Neural Mechanisms Mediating Motion Sensitivity in Parasol Ganglion Cells of the Primate Retina. Neuron 97:1327-1340.e4
Giarmarco, Michelle M; Cleghorn, Whitney M; Hurley, James B et al. (2018) Preparing Fresh Retinal Slices from Adult Zebrafish for Ex Vivo Imaging Experiments. J Vis Exp :

Showing the most recent 10 out of 556 publications