The long-term objectives of this project are to conduct clinial studies which will provide new information for understanding, prevention, and management of disorders of the visual system. The first specific aim is to establish a Clinical Reserach CORE Module that will include a biostatistician, clinical coordinator, and computer. This new module will enhance existing and new clinical research projects by providing epidemiologic and biostatistical methodology necessary for conduct of prospective clinical trials, using state-of-the-art data analysis. Examples of projects include: Japanese- American community diabetes study, Yakima diabetic eye screening project, optic neuritis treatment trial, effect of somatostatin analogs on diabetic retinopathy, analysis of dissemination of new knowledge obtained from clinical trials, evaluation of automated perimetry software, evaluation of infant vision testing cards, treatment of Graves' ophthalmopathy, use of intraocular lenses in diabetic patients, clinical pathologic study of eyes from Alzheimer's patients, genetic analysis of ocular coloboma, and application of gene probes for retinal proteins to DNA from patients with inherited retinal dystrophies, including retinitis pigmentosa.
| Manookin, Michael B; Patterson, Sara S; Linehan, Conor M (2018) Neural Mechanisms Mediating Motion Sensitivity in Parasol Ganglion Cells of the Primate Retina. Neuron 97:1327-1340.e4 |
| Giarmarco, Michelle M; Cleghorn, Whitney M; Hurley, James B et al. (2018) Preparing Fresh Retinal Slices from Adult Zebrafish for Ex Vivo Imaging Experiments. J Vis Exp : |
| Patterson, Emily J; Kalitzeos, Angelos; Kasilian, Melissa et al. (2018) Residual Cone Structure in Patients With X-Linked Cone Opsin Mutations. Invest Ophthalmol Vis Sci 59:4238-4248 |
| Pepple, Kathryn L; Nguyen, Macklin H; Pakzad-Vaezi, Kaivon et al. (2018) RESPONSE OF INFLAMMATORY CYSTOID MACULAR EDEMA TO TREATMENT USING ORAL ACETAZOLAMIDE. Retina : |
| Pakzad-Vaezi, Kaivon; Khaksari, Kosar; Chu, Zhongdi et al. (2018) Swept-Source OCT Angiography of Serpiginous Choroiditis. Ophthalmol Retina 2:712-719 |
| Bleckert, Adam; Zhang, Chi; Turner, Maxwell H et al. (2018) GABA release selectively regulates synapse development at distinct inputs on direction-selective retinal ganglion cells. Proc Natl Acad Sci U S A 115:E12083-E12090 |
| Kerov, Vasily; Laird, Joseph G; Joiner, Mei-Ling et al. (2018) ?2?-4 Is Required for the Molecular and Structural Organization of Rod and Cone Photoreceptor Synapses. J Neurosci 38:6145-6160 |
| Pepple, Kathryn L; Wilson, Leslie; Van Gelder, Russell N (2018) Comparison of Aqueous and Vitreous Lymphocyte Populations From Two Rat Models of Experimental Uveitis. Invest Ophthalmol Vis Sci 59:2504-2511 |
| Lee, Cecilia S; Lee, Aaron Y; Akileswaran, Lakshmi et al. (2018) Determinants of Outcomes of Adenoviral Keratoconjunctivitis. Ophthalmology 125:1344-1353 |
| Coates, Daniel R; Levi, Dennis M; Touch, Phanith et al. (2018) Foveal Crowding Resolved. Sci Rep 8:9177 |
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