Abstract

The Core Facilities Grant for the Wilmer Institute provides key support for a variety of research activities at this, the largest eye institute in the US. During the 3 decades of funding, our shared facilities have served an increasing number of R, K, and U awards. We plan to continue to utilize our existing core modules: microscopy/imaging, computer, machine shop, and biostatistics. In addition, we have demonstrated through initially department-generated funding that there is a need for a new module to serve the area of bioinformatics. Each of the existing modules will continue to evolve in the service of investigators with the latest in research technology. Specific examples include the addition of a new digital transmission electron microscope and image processing software, expanded computer programming support, and expanded biostatistical consultations in a variety of areas.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001765-32
Application #
7250159
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Chin, Hemin R
Project Start
1997-07-01
Project End
2009-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
32
Fiscal Year
2007
Total Cost
$817,399
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Sharma, Anjali; Porterfield, Joshua E; Smith, Elizabeth et al. (2018) Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model. J Control Release 283:175-189
Kimball, Elizabeth C; Jefferys, Joan L; Pease, Mary E et al. (2018) The effects of age on mitochondria, axonal transport, and axonal degeneration after chronic IOP elevation using a murine ocular explant model. Exp Eye Res 172:78-85
Nesper, Peter L; Lutty, Gerard A; Fawzi, Amani A (2018) RESIDUAL CHOROIDAL VESSELS IN ATROPHY CAN MASQUERADE AS CHOROIDAL NEOVASCULARIZATION ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Introducing a Clinical and Software Approach. Retina 38:1289-1300
Gilbert-Honick, Jordana; Ginn, Brian; Zhang, Yuanfan et al. (2018) Adipose-derived Stem/Stromal Cells on Electrospun Fibrin Microfiber Bundles Enable Moderate Muscle Reconstruction in a Volumetric Muscle Loss Model. Cell Transplant :963689718805370
Zhang, Zhi; Jyoti, Amar; Balakrishnan, Bindu et al. (2018) Trajectory of inflammatory and microglial activation markers in the postnatal rabbit brain following intrauterine endotoxin exposure. Neurobiol Dis 111:153-162
Bressler, Eric M; Kim, Jayoung; Shmueli, Ron B et al. (2018) Biomimetic peptide display from a polymeric nanoparticle surface for targeting and antitumor activity to human triple-negative breast cancer cells. J Biomed Mater Res A 106:1753-1764
Liu, Yuanyuan; Fortmann, Seth D; Shen, Jikui et al. (2018) AAV8-antiVEGFfab Ocular Gene Transfer for Neovascular Age-Related Macular Degeneration. Mol Ther 26:542-549
Bhutto, Imran A; Ogura, Shuntaro; Baldeosingh, Rajkumar et al. (2018) An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy. Invest Ophthalmol Vis Sci 59:AMD143-AMD151
Wilson, David R; Sen, Rupashree; Sunshine, Joel C et al. (2018) Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy. Nanomedicine 14:237-246
Fernandes, Kimberly A; Mitchell, Katherine L; Patel, Amit et al. (2018) Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury. Exp Eye Res 171:54-61

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