Abstract

The Core Facilities Grant for the Wilmer Institute provides key support for a variety of research activities at this, the largest eye institute in the US. During the 3 decades of funding, our shared facilities have served an increasing number of R, K, and U awards. We plan to continue to utilize our existing core modules: microscopy/imaging, computer, machine shop, and biostatistics. In addition, we have demonstrated through initially department-generated funding that there is a need for a new module to serve the area of bioinformatics. Each of the existing modules will continue to evolve in the service of investigators with the latest in research technology. Specific examples include the addition of a new digital transmission electron microscope and image processing software, expanded computer programming support, and expanded biostatistical consultations in a variety of areas.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001765-33
Application #
7494476
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Liberman, Ellen S
Project Start
1997-07-01
Project End
2009-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
33
Fiscal Year
2008
Total Cost
$817,392
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Date, Abhijit A; Halpert, Gilad; Babu, Taarika et al. (2018) Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease. Biomaterials 185:97-105
Meyer, Randall A; Mathew, Mohit P; Ben-Akiva, Elana et al. (2018) Anisotropic biodegradable lipid coated particles for spatially dynamic protein presentation. Acta Biomater 72:228-238
Goldberg, Morton F; McLeod, Scott; Tso, Mark et al. (2018) Ocular Histopathology and Immunohistochemical Analysis in the Oldest Known Individual with Autosomal Dominant Vitreoretinochoroidopathy. Ophthalmol Retina 2:360-378
Park, Tea Soon; Zimmerlin, Ludovic; Evans-Moses, Rebecca et al. (2018) Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency. J Vis Exp :
Hinkle, Jared T; Perepezko, Kate; Bakker, Catherine C et al. (2018) Domain-specific cognitive impairment in non-demented Parkinson's disease psychosis. Int J Geriatr Psychiatry 33:e131-e139
Duncan, Gregg A; Kim, Namho; Colon-Cortes, Yanerys et al. (2018) An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy. Mol Ther Methods Clin Dev 9:296-304
Long, Da; Kanan, Yogita; Shen, Jikui et al. (2018) VEGF/VEGFR2 blockade does not cause retinal atrophy in AMD-relevant models. JCI Insight 3:
Liu, Melissa M; Cho, Chris; Jefferys, Joan L et al. (2018) Use of Optical Coherence Tomography by Nonexpert Personnel as a Screening Approach for Glaucoma. J Glaucoma 27:64-70
Ebrahimi, Katayoon B; Cano, Marisol; Rhee, John et al. (2018) Oxidative Stress Induces an Interactive Decline in Wnt and Nrf2 Signaling in Degenerating Retinal Pigment Epithelium. Antioxid Redox Signal 29:389-407
Pitha, Ian; Kimball, Elizabeth C; Oglesby, Ericka N et al. (2018) Sustained Dorzolamide Release Prevents Axonal and Retinal Ganglion Cell Loss in a Rat Model of IOP-Glaucoma. Transl Vis Sci Technol 7:13

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