Abstract

ANIMAL SERVICES CORE The Animal Services Core is structured to meet the evolving needs of investigators for translational research by providing resources to develop experimental animal models of ocular diseases and test the delivery and efficacy of new therapeutic agents. The goals are: 1) to provide expert assistance and oversight in the management of transgenic and gene knockout/knockin animal colonies, including their genotyping; 2) to make available the use of animal facilities and equipment, provide guidance in their utilization, and supervise the performance of animal procedures and tissue harvesting; 3) to make available equipment for development and generation of animal models of ocular diseases and pathologic eye conditions; 4) to provide assistance in imaging of live animals; 5) to serve as a liaison between investigators and the University's animal facilities and services.

Public Health Relevance

ANIMAL SERVICES CORE The Animal Services Core provides shared equipment and technical staff to develop experimental animal models and test new regenerative therapies in translational vision science research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001792-40
Application #
9772472
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2019-09-30
Budget End
2020-09-29
Support Year
40
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Illinois at Chicago
Department
Type
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

McAnany, J Jason; Park, Jason C (2018) Reduced Contrast Sensitivity is Associated With Elevated Equivalent Intrinsic Noise in Type 2 Diabetics Who Have Mild or No Retinopathy. Invest Ophthalmol Vis Sci 59:2652-2658
Zhang, Min; Zhou, Qiang; Luo, Yuncin et al. (2018) Semaphorin3A induces nerve regeneration in the adult cornea-a switch from its repulsive role in development. PLoS One 13:e0191962
McAnany, J Jason; Park, Jason C (2018) Temporal Frequency Abnormalities in Early-Stage Diabetic Retinopathy Assessed by Electroretinography. Invest Ophthalmol Vis Sci 59:4871-4879
Patangay, Shresta; Derafshi, Zahra; Vajaranant, Thasarat S et al. (2018) Three Dimensional Stimulus Source for Pattern Electroretinography in Mid- and Far-peripheral Retina. Transl Vis Sci Technol 7:8
Nannini, Drew R; Kim, Heejin; Fan, Fangda et al. (2018) Genetic Risk Score Is Associated with Vertical Cup-to-Disc Ratio and Improves Prediction of Primary Open-Angle Glaucoma in Latinos. Ophthalmology 125:815-821
Ali, Mohsin H; Azar, Nathalie F; Aakalu, Vinay et al. (2018) Congenital cavitary optic disc anomaly and Axenfeld's anomaly in Wolf-Hirschhorn syndrome: A case report and review of the literature. Ophthalmic Genet 39:271-274
Park, Jason C; Moss, Heather E; McAnany, J Jason (2018) Electroretinography in idiopathic intracranial hypertension: comparison of the pattern ERG and the photopic negative response. Doc Ophthalmol 136:45-55
Calway, Tyler; Rubin, Daniel S; Moss, Heather E et al. (2018) Perioperative Retinal Artery Occlusion: Incidence and Risk Factors in Spinal Fusion Surgery From the US National Inpatient Sample 1998-2013. J Neuroophthalmol 38:36-41
Rouhbakhshzaeri, Majid; Rabiee, Behnam; Azar, Nathalie et al. (2018) New ex vivo model of corneal endothelial phacoemulsification injury and rescue therapy with mesenchymal stromal cell secretome. J Cataract Refract Surg :
Samaeekia, Ravand; Rabiee, Behnam; Putra, Ilham et al. (2018) Effect of Human Corneal Mesenchymal Stromal Cell-derived Exosomes on Corneal Epithelial Wound Healing. Invest Ophthalmol Vis Sci 59:5194-5200

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