Dr. Burke has been principal investigator on our Core Grant since 1985. She has directed the Cell CultureModule since her arrival at this institution in 1982 and the morphology facility both prior to and after its designationas a Core Module in 1992. (Morphology Module leadership was assumed by Dr. Link during this budget cycle.)Dr. Burke is a member of the graduate faculty and in that capacity she mentors graduate students andpostdoctoral fellows and contributes to medical and graduate teaching programs. She is also on the teachingfaculty of an NIH-supported K30 Clinical Research Scholars Program which has a goal of helping junior facultybecome successful clinical and/or translational researchers.In addition to laboratory studies funded by the NEI, Dr. Burke has collaborated for several years with theclinical faculty in the retina section. She and members of her lab meet monthly with the clinicians and other retinaresearchers to discuss research questions of common interest.Since Dr. Burke's work is multidisciplinary, she is a major user of most of the Core modules. The CellCulture Module maintains several types of ocular and nonocular cells, which provide the biological material for herstudies. Many assays performed for her research make use of instrumentation available in the Molecular Biology-Biochemistry Module and most studies also have a morphologic component requiring the services or equipment inthe Morphology Module. Additionally, some of her work is conducted using a transgenic mouse model, whichrequires use of the Animal Resource Module. She is an extensive user of the Image Analysis Module by virtue ofher need for confocal imaging and as the primary user of our live cell imaging system.Dr. Burke served as Executive Vice President of ARVO from 1992 to 1997. In that capacity, she served onthe ARVO Board of Trustees and chaired the ARVO Program Committee, which is responsible for abstract reviewand organization of the scientific program for the ARVO Annual Meeting. This experience exposed her to the fullbreadth of vision research, making her sympathetic to the needs of scientists working outside her area andreceptive to modifying the Core Modules to assure that they continue to meet the needs of as many investigatorsas possible.
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