Many laboratory scientists in our group use animal models for some phasesof their work, and sometimes their animal studies are conducted in collaboration with clinical faculty inOphthalmology. The Animal Resource Module performs the essential function of providing shared space, withequipment dedicated for animal use, where ophthalmic procedures can be conducted. This Module was formerlycalled the 'Animal Surgery Module', but the name was changed during this budget cycle to reflect the fact that it isless frequently used for surgery than in the past. Now it serves as a multi-purpose resource for conducting animalresearch with a primary emphasis on ocular examination and image collection, tissue collection for morphologicand molecular analysis, and performance of minor procedures. Access to well-designed space within theinstitution's vivarium, where the Module is located, assures that we fulfill the requirements for the appropriate careand handling of research animals. Further, having a centralized facility avoids duplication of expensive equipmentand encourages interaction among members of the group with different skills in animal examination andmanipulation. If the Module with its specialized instruments were not available, we would be unable to perform theocular procedures and examinations on the multiple animal species that our group uses.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY001931-31
Application #
7286505
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Project Start
2007-04-01
Project End
2012-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
31
Fiscal Year
2007
Total Cost
$36,180
Indirect Cost
Name
Medical College of Wisconsin
Department
Type
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Hirji, Nashila; Georgiou, Michalis; Kalitzeos, Angelos et al. (2018) Longitudinal Assessment of Retinal Structure in Achromatopsia Patients With Long-Term Follow-up. Invest Ophthalmol Vis Sci 59:5735-5744
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Lapierre-Landry, Maryse; Huckenpahler, Alison L; Link, Brian A et al. (2018) Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography. Transl Vis Sci Technol 7:4
Patterson, Emily J; Kalitzeos, Angelos; Kasilian, Melissa et al. (2018) Residual Cone Structure in Patients With X-Linked Cone Opsin Mutations. Invest Ophthalmol Vis Sci 59:4238-4248
Davidson, Benjamin; Kalitzeos, Angelos; Carroll, Joseph et al. (2018) Automatic Cone Photoreceptor Localisation in Healthy and Stargardt Afflicted Retinas Using Deep Learning. Sci Rep 8:7911
Reid, Christopher A; Nettesheim, Emily R; Connor, Thomas B et al. (2018) Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD. Sci Rep 8:11763

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