The broad objective of this application is to facilitate study of visual system function in health and in binding disease with the aim of preventing, mitigating, or curing such disease through the application of the most sophisticated available techniques, including the methods used in molecular biology and molecular genetics. Four support modules will provide these: . Imaging and Computer Module (computer-aided image and data acquisition and analysis); . Molecular Biology Module (molecular localization in tissues using phosphoimaging, DNA sequencing and gene cloning); . Targeted Mutagenesis and Transgenic Animal Module (targeted mutagenesis and development of transgenic animal models); and . In situ Hybridization Module (in Situ hybridization, combined in situ hybridization and immunocytochemistry, and in situ PCR). This application is a competing renewal of a Core Vision Research Grant submitted by the Principal Investigator and 23 other funded investigators. Twelve are NEI-funded, and seven others are funded by non-NIH sources. Of the latter seven, two are submitting NEI R01 renewals, and three are preparing new NEI RO1 applications.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY002162-22
Application #
2882872
Study Section
Special Emphasis Panel (ZEY1-VSN (02))
Project Start
1977-12-01
Project End
2003-02-28
Budget Start
1999-03-01
Budget End
2000-02-29
Support Year
22
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Alvarado, Jorge A; Srivastava, Vinita; Sun, Yang (2018) Intraluminal Deposits Found in Glaucoma Tube Shunts Via Anterior Segment Ocular Coherence Tomography. J Glaucoma 27:e68-e71
Lee, Jun Hui; Sanchez, Lucia Rivera; Porco, Travis et al. (2018) Correlation of Corneal and Scleral Pneumatonometry in Pediatric Patients. Ophthalmology 125:1209-1214
Narasimhan, Vinayak; Siddique, Radwanul Hasan; Lee, Jeong Oen et al. (2018) Multifunctional biophotonic nanostructures inspired by the longtail glasswing butterfly for medical devices. Nat Nanotechnol 13:512-519
Economides, John R; Rapone, Brittany C; Adams, Daniel L et al. (2018) Normal Topography and Binocularity of the Superior Colliculus in Strabismus. J Neurosci 38:173-182
Moussa, Kareem; Doan, Thuy; Stewart, Jay M et al. (2018) CYTOMEGALOVIRUS RETINITIS ASSOCIATED WITH OCCLUSIVE VASCULOPATHY IN AN ELDERLY, HUMAN IMMUNODEFICIENCY VIRUS-NEGATIVE MAN. Retin Cases Brief Rep 12 Suppl 1:S114-S117
Chansangpetch, Sunee; Prombhul, Sasiprapa; Tantisevi, Visanee et al. (2018) DNA Methylation Status of the Interspersed Repetitive Sequences for LINE-1, Alu, HERV-E, and HERV-K in Trabeculectomy Specimens from Glaucoma Eyes. J Ophthalmol 2018:9171536
LaVail, Matthew M; Nishikawa, Shimpei; Steinberg, Roy H et al. (2018) Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration. Exp Eye Res 167:56-90
Rauen, Katherine A; Schoyer, Lisa; Schill, Lisa et al. (2018) Proceedings of the fifth international RASopathies symposium: When development and cancer intersect. Am J Med Genet A 176:2924-2929
Berlinberg, Elyse J; Deiner, Michael S; Porco, Travis C et al. (2018) Monitoring Interest in Herpes Zoster Vaccination: Analysis of Google Search Data. JMIR Public Health Surveill 4:e10180
Hayashi, Genki; Labelle-Dumais, Cassandre; Gould, Douglas B (2018) Use of sodium 4-phenylbutyrate to define therapeutic parameters for reducing intracerebral hemorrhage and myopathy in Col4a1 mutant mice. Dis Model Mech 11:

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