The broad objective of this Core Vision Research Grant application is to facilitate study of the structure, development and function of the visual system in health and in blinding diseases, with the aim of preventing, mitigating or curing such diseases through the application of the most sophisticated available techniques, including the methods used in molecular biology and molecular genetics. Five support and service modules will help achieve the broad objective, as follows: I. Imaging Support Module (computer-aided image analysis;production of graphics for data analysis, presentation and publication, including poster printing); II. Molecular Biology and Genetic Analysis Service Module (PCR and Southern blot genotyping of transgenic animals and DMA sequencing); III. Confocal and Digital Microscopy Support Module (digital data acquisition using confocal microscopy and optical brightfield, darkfield, phase contrast or fluorescence microscopy); IV. Computer/IT Support Module (assistance in computer and information technology hardware and software selection, installation, instruction in use, maintenance and minor repairs, networking, and programming for custom research needs); V. Electrical and Machine Shop Service Module (design, manufacture, maintenance and repair of specialized research instruments and devices). This application is a competing renewal of a Core Vision Research Grant submitted by the Principal Investigator and 32 other funded vision scientists. Twenty are NEI-funded with 23 separate research projects (R01, K08 and K23), 5 are funded by other NEI mechanisms, one is NIH- but not NEI-funded, and 8 others are funded by private, non-NIH sources. Of the latter 8, two are newly recruited vision scientists who plan to submit new NEI R01 grant applications, and two others are more senior scientists who plan to resubmit productive R01 applications in the near future. Overall, Core investigators are involved in 38 different, active research projects. The Core Vision Research Grant has been highly successful in enhancing the productivity of vision research and facilitating collaborative studies on the visual system at UCSF.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY002162-34
Application #
8045420
Study Section
Special Emphasis Panel (ZEY1-VSN (04))
Program Officer
Liberman, Ellen S
Project Start
1997-03-01
Project End
2013-02-28
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
34
Fiscal Year
2011
Total Cost
$737,853
Indirect Cost
Name
University of California San Francisco
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Chansangpetch, Sunee; Nguyen, Anwell; Mora, Marta et al. (2018) Agreement of Anterior Segment Parameters Obtained From Swept-Source Fourier-Domain and Time-Domain Anterior Segment Optical Coherence Tomography. Invest Ophthalmol Vis Sci 59:1554-1561
Lew, Young Ju; Rinella, Nicholas; Qin, Jia et al. (2018) High-resolution Imaging in Male Germ Cell-Associated Kinase (MAK)-related Retinal Degeneration. Am J Ophthalmol 185:32-42
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Ramirez, David A; Porco, Travis C; Lietman, Thomas M et al. (2018) Ocular Injury in United States Emergency Departments: Seasonality and Annual Trends Estimated from a Nationally Representative Dataset. Am J Ophthalmol 191:149-155
Hirabayashi, Kristin E; Moore, Anthony T; Mendelsohn, Bryce A et al. (2018) Congenital sodium diarrhea and chorioretinal coloboma with optic disc coloboma in a patient with biallelic SPINT2 mutations, including p.(Tyr163Cys). Am J Med Genet A 176:997-1000
Alvarado, Jorge A; Srivastava, Vinita; Sun, Yang (2018) Intraluminal Deposits Found in Glaucoma Tube Shunts Via Anterior Segment Ocular Coherence Tomography. J Glaucoma 27:e68-e71
Lee, Jun Hui; Sanchez, Lucia Rivera; Porco, Travis et al. (2018) Correlation of Corneal and Scleral Pneumatonometry in Pediatric Patients. Ophthalmology 125:1209-1214

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