Abstract

This application represents a competing renewal for a Vision Research Core Center Grant, now in it's tenth year, which funds support facilities and services for 25 researchers that comprise the Core faculty in the Cullen Eye Institute, Baylor College of Medicine. Major program areas include diseases of the retina and choroid: the cornea; and the sensory- motor visual system. Research activities include investigation of the anatomy, biochemistry, cell biology, physiology, molecular biology, immunology and pathology of the neural retina, retinal pigment epithelium, choroid, retinal organization and information processing, lens and cataractogenesis, the role of herpes viruses and corneal disease, endogenous fungal endophthalmitis, glaucoma and visual dysfunction in stabismus and amblyopia. Eight basic research support modules are proposed and are listed below in order of our prioritized needs. -Administration-Research Photography-Image Analysis-Electron Microscopy- Equipment-Research Workshop-Molecular Biology-Animal Facilities In addition, a clinical research support module is also proposed which will bring clinical researchers into our Core who have not previously been supported through this mechanism.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY002520-14
Application #
3102529
Study Section
Vision Research and Training Committee (VSN)
Project Start
1979-07-01
Project End
1994-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
14
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Xiao, Yangyan; de Paiva, Cintia S; Yu, Zhiyuan et al. (2018) Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol 30:457-470
Wang, Jun; Zhao, Li; Wang, Xia et al. (2018) GRIPT: a novel case-control analysis method for Mendelian disease gene discovery. Genome Biol 19:203
Wang, Hongxia; Dewell, Richard B; Zhu, Ying et al. (2018) Feedforward Inhibition Conveys Time-Varying Stimulus Information in a Collision Detection Circuit. Curr Biol 28:1509-1521.e3
Zhu, Ying; Dewell, Richard B; Wang, Hongxia et al. (2018) Pre-synaptic Muscarinic Excitation Enhances the Discrimination of Looming Stimuli in a Collision-Detection Neuron. Cell Rep 23:2365-2378
Dewell, Richard Burkett; Gabbiani, Fabrizio (2018) Biophysics of object segmentation in a collision-detecting neuron. Elife 7:
Ko, Byung Yi; Xiao, Yangyan; Barbosa, Flavia L et al. (2018) Goblet cell loss abrogates ocular surface immune tolerance. JCI Insight 3:
Shen, Guofu; Link, Schuyler; Kumar, Sandeep et al. (2018) Characterization of Retinal Ganglion Cell and Optic Nerve Phenotypes Caused by Sustained Intracranial Pressure Elevation in Mice. Sci Rep 8:2856
Eblimit, Aiden; Agrawal, Smriti Akshay; Thomas, Kandace et al. (2018) Conditional loss of Spata7 in photoreceptors causes progressive retinal degeneration in mice. Exp Eye Res 166:120-130
Denfield, George H; Ecker, Alexander S; Shinn, Tori J et al. (2018) Attentional fluctuations induce shared variability in macaque primary visual cortex. Nat Commun 9:2654
Wang, Changjun; Zaheer, Mahira; Bian, Fang et al. (2018) Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci 19:

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