This application requests renewal of a Core Grant to support 25 vision research investigators with 15 qualifying NEI R01 grants, 2 NEI R21 grants, 1 U10 grant, 1 NEI-funded Research Development Center grant (PN1) and 2 NEI-funded training (T32) grants at Baylor College of Medicine. In this competing renewal application, we report our highly successful and productive past usage of the Core facilities (with a large number of publications benefitting from the Core Modules and high level of collaborations among Core members), and seek continued support for three modules based on the current needs and emerging demand for cutting-edge technology of the vision research community. The proposed Modules are Microscopy, Digital Imaging &Histology;Machine Shop;and Small Animal Visual System Analysis.
The aim of the proposal is to provide support and facilities, essential for progress on NEI-funded projects, net available among the departments and which cannot be obtained through individual research grants.
The specific aims of the application are (1) Te provide a state-of-the-art scanning confocal microscope for high resolution three-dimensional imaging and an advanced transmission electron microscope for ultrastructural analysis of ocular and neural tissues, and molecular imaging. (2) To provide facilities and services to process digital images obtained from confocal, conventional light and electron microscopes;histological facilities, and services and training for both light and electron microscopy. (3) To provide in-house machine shop services to the Vision Core investigators who need special apparatus not commercially available. (4) To design and fabricate high-precision devices for vision Core laboratories with the new state-of-the-art 5-axes machine. (5) To provide facilities not available in individual laboratories for characterizing animal models (mice rats and rabbits) of ocular disease. These include instruments for biochemical analysis of proteins and small molecules, and functional analysis of vision using electroretinography (ERG) and opto-metor reflex assays (6) To foster collaborations among vision researcher groups at Baylor through sharing of common facilities. (7) To provide a supportive environment to attract and retain outstanding vision research faculty, students and postdoctoral fellows;and facilitate new vision research projects.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY002520-33
Application #
8288849
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Liberman, Ellen S
Project Start
1997-07-01
Project End
2015-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
33
Fiscal Year
2012
Total Cost
$559,799
Indirect Cost
$195,109
Name
Baylor College of Medicine
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Xiao, Yangyan; de Paiva, Cintia S; Yu, Zhiyuan et al. (2018) Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol 30:457-470
Wang, Jun; Zhao, Li; Wang, Xia et al. (2018) GRIPT: a novel case-control analysis method for Mendelian disease gene discovery. Genome Biol 19:203
Wang, Hongxia; Dewell, Richard B; Zhu, Ying et al. (2018) Feedforward Inhibition Conveys Time-Varying Stimulus Information in a Collision Detection Circuit. Curr Biol 28:1509-1521.e3
Zhu, Ying; Dewell, Richard B; Wang, Hongxia et al. (2018) Pre-synaptic Muscarinic Excitation Enhances the Discrimination of Looming Stimuli in a Collision-Detection Neuron. Cell Rep 23:2365-2378
Dewell, Richard Burkett; Gabbiani, Fabrizio (2018) Biophysics of object segmentation in a collision-detecting neuron. Elife 7:
Ko, Byung Yi; Xiao, Yangyan; Barbosa, Flavia L et al. (2018) Goblet cell loss abrogates ocular surface immune tolerance. JCI Insight 3:
Shen, Guofu; Link, Schuyler; Kumar, Sandeep et al. (2018) Characterization of Retinal Ganglion Cell and Optic Nerve Phenotypes Caused by Sustained Intracranial Pressure Elevation in Mice. Sci Rep 8:2856
Eblimit, Aiden; Agrawal, Smriti Akshay; Thomas, Kandace et al. (2018) Conditional loss of Spata7 in photoreceptors causes progressive retinal degeneration in mice. Exp Eye Res 166:120-130
Denfield, George H; Ecker, Alexander S; Shinn, Tori J et al. (2018) Attentional fluctuations induce shared variability in macaque primary visual cortex. Nat Commun 9:2654
Wang, Changjun; Zaheer, Mahira; Bian, Fang et al. (2018) Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci 19:

Showing the most recent 10 out of 349 publications