The Core Grant for Vision Research will maintain and expand the common facilities of the Vision Research Center established in the Department of Ophthalmology at Washington University 11 years ago to provide essential services for faculty members whose research interests are in one or another aspect of vision. The Vision Research Center facilitates the interaction between several investigators and makes it possible for them to advance their ongoing research, most of which is supported by individual research grants from NEI. The current application requests continued support for a Service Module, which consists of a machine shop and an electronics shop. In addition there has been a recent change in the chairmanship of the Department of Ophthalmology and Visual Sciences. There has been renewed commitment to research as evidenced by a dramatic increase in the research faculty, as well as renovation and construction of new laboratory space. Therefore, support is also requested for an Immunology Module, a Molecular Biology Module, and a Biostatistics Module to meet the increased needs of the vision research faculty. The research environment at Washington University is very interactive and extends across departmental boundaries. Consequently, a number of the participants in the Core Grant for Vision Research have primary appointments in departments other than that in the Department of Ophthalmology and Visual Sciences.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY002687-12
Application #
3102541
Study Section
Vision Research and Training Committee (VSN)
Project Start
1978-12-01
Project End
1995-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
12
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Gordon, Mae O; Higginbotham, Eve J; Heuer, Dale K et al. (2018) Assessment of the Impact of an Endpoint Committee in the Ocular Hypertension Treatment Study. Am J Ophthalmol :
Ruzycki, Philip A; Zhang, Xiaodong; Chen, Shiming (2018) CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites. Epigenetics Chromatin 11:42
Brightman, Diana S; Grant, Rachel L; Ruzycki, Philip A et al. (2018) MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity. Sci Rep 8:11902
Hamilton, Paul D; Andley, Usha P (2018) In vitro interactions of histones and ?-crystallin. Biochem Biophys Rep 15:7-12
Lin, Jonathan B; Moolani, Harsh V; Sene, Abdoulaye et al. (2018) Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration. JCI Insight 3:
Kraus, Courtney L; Culican, Susan M (2018) New advances in amblyopia therapy II: refractive therapies. Br J Ophthalmol 102:1611-1614
Ban, Norimitsu; Lee, Tae Jun; Sene, Abdoulaye et al. (2018) Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. JCI Insight 3:
Lin, Jonathan B; Kubota, Shunsuke; Mostoslavsky, Raul et al. (2018) Role of Sirtuins in Retinal Function Under Basal Conditions. Adv Exp Med Biol 1074:561-567
Vinberg, Frans; Chen, Jeannie; Kefalov, Vladimir J (2018) Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors. Prog Retin Eye Res 67:87-101
Majtan, Tomas; Jones Jr, Wendell; Krijt, Jakub et al. (2018) Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther 26:834-844

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