The Biostatistics Module designs and implements studies to provide planning data for R01 and U10 proposals. The module also provides statistical and methodological expertise in study design and analysis of data. Expertise is provided to insure validity of statistical analyses and conclusions. The biostatistics module trains clinicians and basic scientists in research methodology and statistics. The biostatistics module provides a rapid response capability to help investigators quickly answer manuscript reviews, and advises on appropriate new measurements or data analysis methods to address reviewer concerns. The environment for research is enhanced by access to expert biostatisticians who understand the vision system and its diseases and who can appreciate the practical difficulties often encountered at the lab bench or in the clinical setting.
| Gordon, Mae O; Higginbotham, Eve J; Heuer, Dale K et al. (2018) Assessment of the Impact of an Endpoint Committee in the Ocular Hypertension Treatment Study. Am J Ophthalmol : |
| Ruzycki, Philip A; Zhang, Xiaodong; Chen, Shiming (2018) CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites. Epigenetics Chromatin 11:42 |
| Brightman, Diana S; Grant, Rachel L; Ruzycki, Philip A et al. (2018) MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity. Sci Rep 8:11902 |
| Hamilton, Paul D; Andley, Usha P (2018) In vitro interactions of histones and ?-crystallin. Biochem Biophys Rep 15:7-12 |
| Lin, Jonathan B; Moolani, Harsh V; Sene, Abdoulaye et al. (2018) Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration. JCI Insight 3: |
| Kraus, Courtney L; Culican, Susan M (2018) New advances in amblyopia therapy II: refractive therapies. Br J Ophthalmol 102:1611-1614 |
| Ban, Norimitsu; Lee, Tae Jun; Sene, Abdoulaye et al. (2018) Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. JCI Insight 3: |
| Lin, Jonathan B; Kubota, Shunsuke; Mostoslavsky, Raul et al. (2018) Role of Sirtuins in Retinal Function Under Basal Conditions. Adv Exp Med Biol 1074:561-567 |
| Vinberg, Frans; Chen, Jeannie; Kefalov, Vladimir J (2018) Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors. Prog Retin Eye Res 67:87-101 |
| Majtan, Tomas; Jones Jr, Wendell; Krijt, Jakub et al. (2018) Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther 26:834-844 |
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