Continued support for our Core Grant for Vision Research is requested. The Core consists of five modules: Biometry, Histology/Immunopathology, Tissue Culture/Instrumentation, Ultrastructure/Morphometry and Vivarium. The laboratory modules have been successful and heavily utilized, supporting over 200 publications involving 32 faculty and over 100 collaborations among Doheny faculty during the last five years. The Biometry module was funded 14 months ago and has been very active during the past 9 months, producing 5 protocols and working with 15 clinicians. We propose to continue our Core activities as they are currently constituted, with full-time salary support for our laboratory supervisors; quarter-time salary for the director of Biometry module, full-time salary for a statistician and a half-time salary support for a clinical coordinator. In addition, we have proposed a limited supply and equipment maintenance budget for each module.
| Kim, Hwa Sun; Huang, Shun-Ping; Lee, Eun-Jin et al. (2018) Identifying Key Networks Linked to Light-Independent Photoreceptor Degeneration in Visual Arrestin 1 Knockout Mice. Adv Exp Med Biol 1074:281-287 |
| Gonzalez Jr, Jose M; Ko, Minhee K; Masedunskas, Andrius et al. (2017) Toward in vivo two-photon analysis of mouse aqueous outflow structure and function. Exp Eye Res 158:161-170 |
| Carelli, Valerio; La Morgia, Chiara; Ross-Cisneros, Fred N et al. (2017) Optic neuropathies: the tip of the neurodegeneration iceberg. Hum Mol Genet 26:R139-R150 |
| Kim, Esther Lee; Tran, Jeffrey; Töteberg-Harms, Marc et al. (2017) Vision Loss and Recovery after Baerveldt Aqueous Tube Shunt Implantation. J Ophthalmol 2017:4140305 |
| Deming, Janise D; Van Craenenbroeck, Kathleen; Eom, Yun Sung et al. (2016) Characterization of Antibodies to Identify Cellular Expression of Dopamine Receptor 4. Adv Exp Med Biol 854:663-70 |
| Choudhury, Farzana; Varma, Rohit; Klein, Ronald et al. (2016) Age-Related Macular Degeneration and Quality of Life in Latinos: The Los Angeles Latino Eye Study. JAMA Ophthalmol 134:683-90 |
| Gonzalez Jr, Jose M; Ammar, Michael J; Ko, MinHee K et al. (2016) Optimizing two-photon multiple fluorophore imaging of the human trabecular meshwork. Mol Vis 22:203-12 |
| Ishikawa, Keijiro; Kannan, Ram; Hinton, David R (2016) Molecular mechanisms of subretinal fibrosis in age-related macular degeneration. Exp Eye Res 142:19-25 |
| Carelli, Valerio; d'Adamo, Pio; Valentino, Maria Lucia et al. (2016) Parsing the differences in affected with LHON: genetic versus environmental triggers of disease conversion. Brain 139:e17 |
| Gonzalez, Jose M; Ko, Minhee K; Pouw, Andrew et al. (2016) Tissue-based multiphoton analysis of actomyosin and structural responses in human trabecular meshwork. Sci Rep 6:21315 |
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