The primary objectives of this Core Grant for Vision Research are to strengthen ongoing collaborative research activities and stimulate new interdisciplinary and interdepartmental research by providing core support for several modules to be made available as common research facilities to investigators of Vision and its Disorders. These modules include: an Animal Surgery Module, a Morphology Module, a Biochemistry/Molecular Biology Module, and an Administrative Module. These facilities provide services and shared resources for collaborative studies on eye related research projects that conform with the NEI national research plan. The various modules will enable us to strengthen our collaborative efforts among scientists of various disciplines in the Departments of Biochemistry, Cell Biology, Immunology, Medicine, Neurobiology, Ophthalmology, Pathology, Psychology, and Radiology at Duke University and the Departments of Cell Biology, Anatomy and Physiology at the University of North Carolina and the Departments of Anatomy/Physiology at North Carolina State University. The Animal Surgery Module will foster collaborative research by making it possible for investigators from diverse disciplines to carry out surgery and experiments together in a facility specifically designed and equipped for ophthalmic procedures in a Eye Center in which basic scientists and clinical ophthalmologists work in harmony. The Ocular Morphology Module with its components in the Departments of Cell Biology and Ophthalmology will provide services enabling co-investigators from different disciplines to correlate histologic, autoradiographic and ultrastructural observations with biochemical, physiological or clinical alterations in ocular disease. The Biochemistry/Molecular Biology Module will provide equipment and facilities that would not otherwise be available to individual investigators. The Administrative Module will coordinate the various eye related research activities and provide the necessary resources for the administration of the Core Grant.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Vision Research and Training Committee (VSN)
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Duke University
Schools of Medicine
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Malek, Goldis; Busik, Julia; Grant, Maria B et al. (2018) Models of retinal diseases and their applicability in drug discovery. Expert Opin Drug Discov 13:359-377
Choudhary, Mayur; Safe, Stephen; Malek, Goldis (2018) Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor. Biochim Biophys Acta Mol Basis Dis 1864:1583-1595
Toomey, Christopher B; Landowski, Michael; Klingeborn, Mikael et al. (2018) Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci 59:662-673
Travis, Amanda M; Heflin, Stephanie J; Hirano, Arlene A et al. (2018) Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells. J Neurosci 38:723-732
Toomey, Christopher B; Johnson, Lincoln V; Bowes Rickman, Catherine (2018) Complement factor H in AMD: Bridging genetic associations and pathobiology. Prog Retin Eye Res 62:38-57
Hirt, Joshua; Porter, Kris; Dixon, Angela et al. (2018) Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model. Cell Death Discov 4:14
Ban, Norimitsu; Lee, Tae Jun; Sene, Abdoulaye et al. (2018) Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. JCI Insight 3:
Dubose, Theodore B; Cunefare, David; Cole, Elijah et al. (2018) Statistical Models of Signal and Noise and Fundamental Limits of Segmentation Accuracy in Retinal Optical Coherence Tomography. IEEE Trans Med Imaging 37:1978-1988
Khaled, Mariam Lofty; Bykhovskaya, Yelena; Yablonski, Sarah E R et al. (2018) Differential Expression of Coding and Long Noncoding RNAs in Keratoconus-Affected Corneas. Invest Ophthalmol Vis Sci 59:2717-2728
McDonnell, Fiona; Dismuke, W Michael; Overby, Darryl R et al. (2018) Pharmacological regulation of outflow resistance distal to Schlemm's canal. Am J Physiol Cell Physiol 315:C44-C51

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