Continued support is requested for the NEI Core Center Grant in the Department of Ophthalmology at Emory University. This Core Center Grant renewal application includes three Modules: (1) Structural Biology, (2) Analytical Biochemistry/Molecular Biology, and (3) Epidemiology and Biostatistics. The past Core Center Grant has been successfully utilized supporting collaborative vision research and service involving 33 faculty (including more than 20 NEI funded principal investigators), 20 postdoctoral fellows, six predoctoral fellows and generating over 250 publications. Renewal of these basic Core activities will allow us to maintain and expand this high level of productivity in vision research. The scope of research services proposed for each of the Modules reflect expanded scientific capabilities. The Structural Biology Module adds immunohistochemistry and confocal microscopy to the light and electron microscopy services provided by the former Morphology/Pathology Module. With the addition of 7,000 square feet of new research space dedicated to molecular biology an molecular genetics research in the Department of Ophthalmology, we are now able to expand the former analytical biochemistry module into a new Analytical Biochemistry/Molecular Biology Module. The Epidemiology and Biostatistics Module proposes to expand its services to basic research projects as well as clinical research projects. The Core Modules have and will continue to enhance our research environment productivity by providing common centralized services to stimulate and facilitate collaborative studies between faculty and to attract other university disciplines to vision research. This Core facility also serves as a centralized vision research facility in Atlanta where faculty from Emory University, Yerkes Regional Primate Center, Morehouse School of medicine, Georgia Institute of Technology, Georgia State University, the Veterans Administration Medical Center and the Centers for Disease Control and Prevention can undertake collaborative studies in vision research.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY006360-14
Application #
2888221
Study Section
Special Emphasis Panel (SRC (01))
Project Start
1986-04-01
Project End
2001-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
14
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Emory University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Peragallo, Jason H; Soares, Bruno P (2018) Vanishing Act: Gorham-Stout Disease Leading to Dynamic Cerebrospinal Fluid Abnormalities. J Neuroophthalmol 38:419-421
Struebing, Felix L; King, Rebecca; Li, Ying et al. (2018) Transcriptional Changes in the Mouse Retina after Ocular Blast Injury: A Role for the Immune System. J Neurotrauma 35:118-129
Dattilo, Michael; Newman, Nancy J; Biousse, Valérie (2018) Acute retinal arterial ischemia. Ann Eye Sci 3:
Kang, Seong Su; Ahn, Eun Hee; Zhang, Zhentao et al. (2018) ?-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease. EMBO J 37:
Lu, Ye; Zhou, Diana; King, Rebecca et al. (2018) The genetic dissection of Myo7a gene expression in the retinas of BXD mice. Mol Vis 24:115-126
Peragallo, Jason H; Keller, Stephanie; van der Knaap, Marjo S et al. (2018) Retinopathy and optic atrophy: Expanding the phenotypic spectrum of pathogenic variants in the AARS2 gene. Ophthalmic Genet 39:99-102
Struebing, Felix L; King, Rebecca; Li, Ying et al. (2018) Genomic loci modulating retinal ganglion cell death following elevated IOP in the mouse. Exp Eye Res 169:61-67
Liao, Albert; Mittal, Pardeep; Lawson, David H et al. (2018) Radiologic and Histopathologic Correlation of Different Growth Patterns of Metastatic Uveal Melanoma to the Liver. Ophthalmology 125:597-605
Liu, Yi-Hsia; Corbett, Clare; Klaska, Izabela P et al. (2018) Partial retinal photoreceptor loss in a transgenic mouse model associated with reduced levels of interphotoreceptor retinol binding protein (IRBP, RBP3). Exp Eye Res 172:54-65
Smith, Jesse M; Ward, Laura T; Townsend, Justin H et al. (2018) Rhegmatogenous Retinal Detachment in Children: Clinical Factors Predictive of Successful Surgical Repair. Ophthalmology :

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