Continued support is requested for the NEI Core Center Grant in the Department of Ophthalmology at Emory University. This Core Center Grant renewal application includes three Modules: (1) Structural Biology, (2) Analytical Biochemistry/Molecular Biology, and (3) Epidemiology and Biostatistics. The past Core Center Grant has been successfully utilized supporting collaborative vision research and service involving 33 faculty (including more than 20 NEI funded principal investigators), 20 postdoctoral fellows, six predoctoral fellows and generating over 250 publications. Renewal of these basic Core activities will allow us to maintain and expand this high level of productivity in vision research. The scope of research services proposed for each of the Modules reflect expanded scientific capabilities. The Structural Biology Module adds immunohistochemistry and confocal microscopy to the light and electron microscopy services provided by the former Morphology/Pathology Module. With the addition of 7,000 square feet of new research space dedicated to molecular biology an molecular genetics research in the Department of Ophthalmology, we are now able to expand the former analytical biochemistry module into a new Analytical Biochemistry/Molecular Biology Module. The Epidemiology and Biostatistics Module proposes to expand its services to basic research projects as well as clinical research projects. The Core Modules have and will continue to enhance our research environment productivity by providing common centralized services to stimulate and facilitate collaborative studies between faculty and to attract other university disciplines to vision research. This Core facility also serves as a centralized vision research facility in Atlanta where faculty from Emory University, Yerkes Regional Primate Center, Morehouse School of medicine, Georgia Institute of Technology, Georgia State University, the Veterans Administration Medical Center and the Centers for Disease Control and Prevention can undertake collaborative studies in vision research.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY006360-15
Application #
6178389
Study Section
Special Emphasis Panel (SRC (01))
Program Officer
Helmsen, Ralph J
Project Start
1986-04-01
Project End
2001-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
15
Fiscal Year
2000
Total Cost
$420,182
Indirect Cost
Name
Emory University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Liu, Yi-Hsia; Corbett, Clare; Klaska, Izabela P et al. (2018) Partial retinal photoreceptor loss in a transgenic mouse model associated with reduced levels of interphotoreceptor retinol binding protein (IRBP, RBP3). Exp Eye Res 172:54-65
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