Abstract

The Structural Biology and Imaging (SBI) Core enhances vision research of AVRC members by assisting them in determining the relationship between normal and abnormal tissue structure in eye diseases, disease models and after experimental treatments. This SBI Core provides facilities and services for AVRC members to determine structural changes and how they relate to function through histology, electron microscopy, confocal scanning laser microscopy and experimental animal surgery imaging. The SBI Core also supports obtaining structural data and interpretation of this data for new initiatives of AVRC members with an emphasis on retinal function, retinal degeneration/injury, RPE morphometry, ocular oncology, and gene/drug delivery. The SBI Core enables localization of proteins involved with control of retinal function in health and disease; imaging of tissue changes in retinal and optic nerve degenerations; correlation of RPE morphometric changes with genotype and function; development of imaging techniques for primary and metastatic ocular tumors, including tissue correlations with MRI contrast agents and tele-imaging; and studying ocular tissue changes relative to gene and drug delivery to the posterior ocular compartment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY006360-35
Application #
10011829
Study Section
Special Emphasis Panel (ZEY1)
Project Start
1997-04-01
Project End
2021-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
35
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Landis, Erica G; Yang, Victoria; Brown, Dillon M et al. (2018) Dim Light Exposure and Myopia in Children. Invest Ophthalmol Vis Sci 59:4804-4811
Vancura, Patrick; Csicsely, Erika; Leiser, Annalisa et al. (2018) Rhythmic Regulation of Photoreceptor and RPE Genes Important for Vision and Genetically Associated With Severe Retinal Diseases. Invest Ophthalmol Vis Sci 59:3789-3799
Sergeeva, Elena G; Espinosa-Garcia, Claudia; Atif, Fahim et al. (2018) Neurosteroid allopregnanolone reduces ipsilateral visual cortex potentiation following unilateral optic nerve injury. Exp Neurol 306:138-148
Chien, Hsin; Alston, Christine I; Dix, Richard D (2018) Suppressor of Cytokine Signaling 1 (SOCS1) and SOCS3 Are Stimulated within the Eye during Experimental Murine Cytomegalovirus Retinitis in Mice with Retrovirus-Induced Immunosuppression. J Virol 92:
Roth, Steven; Dreixler, John; Newman, Nancy J (2018) Haemodilution and head-down tilting induce functional injury in the rat optic nerve: A model for peri-operative ischemic optic neuropathy. Eur J Anaesthesiol 35:840-847
Gooding, Sarah W; Chrenek, Micah A; Ferdous, Salma et al. (2018) Set screw homogenization of murine ocular tissue, including the whole eye. Mol Vis 24:690-699
Peragallo, Jason H (2018) Effects of Brain Tumors on Vision in Children. Int Ophthalmol Clin 58:83-95
Harnish, Stacy M; Rodriguez, Amy D; Blackett, Deena Schwen et al. (2018) Aerobic Exercise as an Adjuvant to Aphasia Therapy: Theory, Preliminary Findings, and Future Directions. Clin Ther 40:35-48.e6
Peragallo, Jason H; Soares, Bruno P (2018) Vanishing Act: Gorham-Stout Disease Leading to Dynamic Cerebrospinal Fluid Abnormalities. J Neuroophthalmol 38:419-421
Struebing, Felix L; King, Rebecca; Li, Ying et al. (2018) Transcriptional Changes in the Mouse Retina after Ocular Blast Injury: A Role for the Immune System. J Neurotrauma 35:118-129

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