This P30 proposal requests continued funding to support the operation of five resource modules within the Ophthalmology and Visual Sciences Research Center (OVSRC) at the Eye and Ear Institute of the University of Pittsburgh. The OVSRC provides a home base for the basic and clinical vision research of 22 vision scientists in four departments of the University of Pittsburgh and two departments of Carnegie Mellon University, whose work is advancing the knowledge base on corneal cell biology, glaucoma (imaging, trabecular meshwork stem cell biology and stem cell based therapeutics, and ocular biomechanics), retina (development, stem cell biology and stem cell based therapeutics), visual neuroscience, ocular infectious disease, ocular immunology, and ocular tumors. Ten vision scientists hold 13 qualifying NEI-funded R01 grants (Table 1), 2 vision scientists hold R01 grants that are funded through other NIH institutes despite being highly vision related projects, 2 vision scientists hold R00 grants from the NEI, and one vision scientist holds a KOS award from the NEI. The remaining participants in our Center Core Grant either have applied (5 R01 grants currently pending, many representing first grant applications) or are generating pilot data for planned NEI grants. The Core Grant for Vision Research continues to provide resources, services, and technology that are critical for the vision research efforts at the University of Pittsburgh and Carnegie Mellon University. The Core Grant enhances the overall vision research environment in Pittsburgh by: 1) providing core resources that are critical to the success of vision scientists; 2) enhancing collaboration among vision scientists in the Pittsburgh area, and 3) aiding in the recruitment of new vision scientists to Pittsburgh. For the past 24 years, the CORE grant has continued to enhance vision research in the Pittsburgh area by providing cutting edge technology, and incorporate the new knowledge, skills into research projects, and facilitating collaboration among scientists and physician scientists.

Public Health Relevance

The CORE Grant for Vision Research, now in its 24th year supports the efforts of a diverse group of vision scientists in the Pittsburgh area. The grant provides critical ancillary support to NEI-funded investigators, and also supports pilot studies fo new NEI applications. The services and equipment provided by this grant allow our vision scientists to utilize diverse scientific approaches into their vision research projects.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY008098-28
Application #
9033119
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
Project Start
1997-04-01
Project End
2019-03-31
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
28
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
D'Aiuto, Leonardo; McNulty, James; Hartline, Caroll et al. (2018) R430: A potent inhibitor of DNA and RNA viruses. Sci Rep 8:16662
Kramer, Phillip; Rao, Mahesh; Stinson, Crystal et al. (2018) Aromatase Derived Estradiol Within the Thalamus Modulates Pain Induced by Varicella Zoster Virus. Front Integr Neurosci 12:46
Jan, Ning-Jiun; Sigal, Ian A (2018) Collagen fiber recruitment: A microstructural basis for the nonlinear response of the posterior pole of the eye to increases in intraocular pressure. Acta Biomater 72:295-305
Yang, Bin; Jan, Ning-Jiun; Brazile, Bryn et al. (2018) Polarized light microscopy for 3-dimensional mapping of collagen fiber architecture in ocular tissues. J Biophotonics 11:e201700356
Bernstein, Cassidy S; Anderson, Mitchell T; Gohel, Chintan et al. (2018) The cellular bases of choroid fissure formation and closure. Dev Biol 440:137-151
Guo, Chuanyu; Zou, Jian; Wen, Yi et al. (2018) Apical Cell-Cell Adhesions Reconcile Symmetry and Asymmetry in Zebrafish Neurulation. iScience 3:63-85
Jeon, Sohyun; Rowe, Alexander M; Carroll, Kate L et al. (2018) PD-L1/B7-H1 Inhibits Viral Clearance by Macrophages in HSV-1-Infected Corneas. J Immunol 200:3711-3719
Fu, Jinling; Nagashima, Mikiko; Guo, Chuanyu et al. (2018) Novel Animal Model of Crumbs-Dependent Progressive Retinal Degeneration That Targets Specific Cone Subtypes. Invest Ophthalmol Vis Sci 59:505-518
Vinci, Giuseppe; Ventura, Valérie; Smith, Matthew A et al. (2018) Adjusted regularization of cortical covariance. J Comput Neurosci 45:83-101
Ni, A M; Ruff, D A; Alberts, J J et al. (2018) Learning and attention reveal a general relationship between population activity and behavior. Science 359:463-465

Showing the most recent 10 out of 647 publications