The Vanderbilt Vision Research Center (VVRC) spanning the College of Arts &Science, Peabody College of Education, School of Engineering and School of Medicine requests continued support for five modules. (1) The Animal Care Module provides specialized enrichment, surgical support and veterinary care of nonhuman primates and other large animals and murine electroretinogram phenotyping. (2) The Computer Module provides hardware installation and maintenance, software development for visual displays and real-time data acquisition and analysis, webpage maintenance and production of illustrations for journals, posters and web pages. (3) The Image Processing Module aids acquisition and analysis of functional brain imaging, optical imaging, confocal and standard microscopy and other imaging data. (4) The Gene &Protein Analysis Module provides timely and economical access to gene microarray, protein mass spectrometry and histopathology services. (5) The Shop Module repairs, designs and fabricates specialized optical, mechanical and electronic instruments. Administrative support is included to ensure continued smooth and stable operation of the VVRC research and training missions. Modules are directed by investigators with NEI funding, have talented and experienced staff and provide services that are otherwise not available or would be prohibitively expensive or slow. During the last grant period, each module was used moderately or extensively by more than three investigators. VVRC investigators produced several hundred publications that made fundamental contributions to basic and clinical visual science. This Core grant has increased collaborations between basic and clinical vision researchers across the Vanderbilt campus and with other institutions. The Core grant has improved our ability to recruit world-class vision researchers resulting in extensive NEI-sponsored research at Vanderbilt. The high level of performance of VVRC investigators, which depends on renewed Core grant support, synergizes with campus-wide initiatives in biomedical research and training at Vanderbilt.
The research facilitated by this Core grant seeks to improve our understanding of the eye and visual system in normal and diseased states. This knowledge will be used to improve the diagnosis and treatment of visual impairments.
|Pollins, Alonda C; Boyer, Richard B; Nussenbaum, Marlieke et al. (2018) Comparing Processed Nerve Allografts and Assessing Their Capacity to Retain and Release Nerve Growth Factor. Ann Plast Surg 81:198-202|
|Wang, Zhen; Schey, Kevin L (2018) Quantification of thioether-linked glutathione modifications in human lens proteins. Exp Eye Res 175:83-89|
|Capozzi, Megan E; Giblin, Meredith J; Penn, John S (2018) Palmitic Acid Induces Müller Cell Inflammation that is Potentiated by Co-treatment with Glucose. Sci Rep 8:5459|
|Bolus, W Reid; Peterson, Kristin R; Hubler, Merla J et al. (2018) Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments. Mol Metab 8:86-95|
|Servant, Mathieu; Cassey, Peter; Woodman, Geoffrey F et al. (2018) Neural bases of automaticity. J Exp Psychol Learn Mem Cogn 44:440-464|
|West, Kathryn L; Kelm, Nathaniel D; Carson, Robert P et al. (2018) Myelin volume fraction imaging with MRI. Neuroimage 182:511-521|
|Rohrbough, Jeffrey; Nguyen, Hong-Ngan; Lamb, Fred S (2018) Modulation of ClC-3 gating and proton/anion exchange by internal and external protons and the anion selectivity filter. J Physiol 596:4091-4119|
|Schlegel, Cameron; Lapierre, Lynne A; Weis, Victoria G et al. (2018) Reversible deficits in apical transporter trafficking associated with deficiency in diacylglycerol acyltransferase. Traffic 19:879-892|
|Fischer, Rachel A; Zhang, Yuchen; Risner, Michael L et al. (2018) Impact of Graphene on the Efficacy of Neuron Culture Substrates. Adv Healthc Mater 7:e1701290|
|Cooke, Allison L; Morris, Jamie; Melchior, John T et al. (2018) A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL. J Lipid Res 59:1244-1255|
Showing the most recent 10 out of 847 publications