Support is requested for Core module facilities and services to support research in vision at the University of Florida. We propose to continue and enhance our three existing NEI-supported modules--Cell/Tissue Culture/Immunology--Structural Biology--Molecular Genetics--that are critically needed by many members of the University of Florida vision research community. By means of these Core module facilities we intend to: 1) Enhance the ability of researchers in various departments at the University of Florida to perform studies in vision research using state-of-the-art techniques. Core facilities support and enhance existing eye research efforts across the campus and facilitate new initiatives. 2) Promote collaborative and multidisciplinary studies in vision research. Collaboration, communication and interchange of ideas and expertise already exist in high degree among our investigators and departments. The shared support facilities serve to further bolster the sense of community, common goals and objectives, and increase the amount of interdisciplinary research on important problems in the visual sciences.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY008571-11
Application #
6147665
Study Section
Special Emphasis Panel (ZEY1-VSN (01))
Program Officer
Helmsen, Ralph J
Project Start
1990-04-01
Project End
2005-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
11
Fiscal Year
2000
Total Cost
$429,528
Indirect Cost
Name
University of Florida
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Ku, Cristy A; Chiodo, Vince A; Boye, Sanford L et al. (2015) Viral-mediated vision rescue of a novel AIPL1 cone-rod dystrophy model. Hum Mol Genet 24:670-84
Ezra-Elia, Raaya; Banin, Eyal; Honig, Hen et al. (2014) Flicker cone function in normal and day blind sheep: a large animal model for human achromatopsia caused by CNGA3 mutation. Doc Ophthalmol 129:141-50
Semple-Rowland, Susan L; Berry, Jonathan (2014) Use of lentiviral vectors to deliver and express bicistronic transgenes in developing chicken embryos. Methods 66:466-73
Boye, Sanford L; Peshenko, Igor V; Huang, Wei Chieh et al. (2013) AAV-mediated gene therapy in the guanylate cyclase (RetGC1/RetGC2) double knockout mouse model of Leber congenital amaurosis. Hum Gene Ther 24:189-202
Komáromy, András M; Rowlan, Jessica S; Corr, Amanda T Parton et al. (2013) Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia. Mol Ther 21:1131-41
Mao, Haoyu; Gorbatyuk, Marina S; Rossmiller, Brian et al. (2012) Long-term rescue of retinal structure and function by rhodopsin RNA replacement with a single adeno-associated viral vector in P23H RHO transgenic mice. Hum Gene Ther 23:356-66
Boye, Shannon E; Alexander, John J; Boye, Sanford L et al. (2012) The human rhodopsin kinase promoter in an AAV5 vector confers rod- and cone-specific expression in the primate retina. Hum Gene Ther 23:1101-15
Deng, Wen-Tao; Dinculescu, Astra; Li, Qiuhong et al. (2012) Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats. Invest Ophthalmol Vis Sci 53:1895-904
Gorbatyuk, Marina S; Gorbatyuk, Oleg S; LaVail, Matthew M et al. (2012) Functional rescue of P23H rhodopsin photoreceptors by gene delivery. Adv Exp Med Biol 723:191-7
Simons, David L; Boye, Sanford L; Hauswirth, William W et al. (2011) Gene therapy prevents photoreceptor death and preserves retinal function in a Bardet-Biedl syndrome mouse model. Proc Natl Acad Sci U S A 108:6276-81

Showing the most recent 10 out of 116 publications