Abstract

- MOLECULAR GENETICS AND BIOSTATISTICS The Molecular Genetics and Biostatistical module continues to provide essential support to NEI PIs including DNA isolation from blood samples, saliva and tissue, as well as, assistance in biostatistical analysis of the data resulting from their work. Access to patient DNA samples is critical for genetic analysis of susceptibility factors in ocular diseases. Having a dedicated facility for the isolation of DNA ensures maximal DNA yield from patient material, as well as, reducing exposure to hazardous biological materials. The biostatistical portion of this module allows NEI investigators access to the most advanced techniques ensuring that the appropriate method is used in the analysis of often extremely large datasets. The support given by this module has been an important factor in the success of OHSU junior faculty obtaining NEI funding in the past 5 years, including Drs. Kate Keller, Shandiz Tehrani and Phoebe Lin. Continuation of the core will be key to assisting new investigators at OHSU obtaining NEI funding in the next 5 years.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY010572-24
Application #
9552821
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
24
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Hegarty, Deborah M; David, Larry L; Aicher, Sue A (2018) Lacrimal Gland Denervation Alters Tear Protein Composition and Impairs Ipsilateral Eye Closures and Corneal Nociception. Invest Ophthalmol Vis Sci 59:5217-5224
Pennesi, Mark E; Birch, David G; Jayasundera, K Thiran et al. (2018) Prospective Evaluation of Patients With X-Linked Retinoschisis During 18 Months. Invest Ophthalmol Vis Sci 59:5941-5956
Patel, Rachel; Wang, Jie; Campbell, J Peter et al. (2018) Classification of Choroidal Neovascularization Using Projection-Resolved Optical Coherence Tomographic Angiography. Invest Ophthalmol Vis Sci 59:4285-4291
Ting, Daniel Shu Wei; Pasquale, Louis R; Peng, Lily et al. (2018) Artificial intelligence and deep learning in ophthalmology. Br J Ophthalmol :
Al-Qahtani, Abdullah A; Ba-Ali, Shakoor; Alabduljalil, Talal et al. (2018) SCLERAL PITS IN CHOROIDEREMIA: Implications for Retinal Gene Therapy. Retina 38:1725-1730
Lu, Jonathan E; Francis, Jasmine H; Dunkel, Ira J et al. (2018) Metastases and death rates after primary enucleation of unilateral retinoblastoma in the USA 2007-2017. Br J Ophthalmol :
Spain, Rebecca I; Liu, Liang; Zhang, Xinbo et al. (2018) Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis. Br J Ophthalmol 102:520-524
Hulett, Tyler W; Jensen, Shawn M; Wilmarth, Phillip A et al. (2018) Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination. J Immunother Cancer 6:27
Boese, Erin A; Huang, David; Tehrani, Shandiz (2018) Unilateral Double Optic Nerve Head Pits. Ophthalmology 125:458
Vranka, Janice A; Staverosky, Julia A; Reddy, Ashok P et al. (2018) Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures. Invest Ophthalmol Vis Sci 59:246-259

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