Abstract

In the previous funding period, Histology was administratively part of the Tissue Culture and Cell Analysis Module; however, due to changes in investigator needs, increased microscopy and imaging capacity, we have now combined Histology with Imaging and added Microscopy. The Histology, Microscopy and Imaging (HMI) Module will occupy two rooms jn the consolidated VSRC Core Grant facility in the Institute of Pathology, with a third room containing animal photography equipment. Three highly qualified individuals will conduct the functions for this Module: Scott Howell, Ph.D. will manage the overall functions of the Module and specifically work with the moderate and extensive users for the Microscopy and Imaging functions of the Module including laser capture microscopy (LCM); Catherine Doller will be in charge of the Histology facility as Co-Manager, and Mark Harrod, the Imaging Manager in the previous funding period, will remain on a part-time basis to oversee the animal photography functions as Co-Manager of the Digital Imaging function. This Module will also be responsible for updating the VSRC website www.case.edu/med/vsrc/.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY011373-12
Application #
7616512
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
12
Fiscal Year
2008
Total Cost
$239,263
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Mallory, D Paul; Gutierrez, Elizabeth; Pinkevitch, Margaret et al. (2018) The Retinitis Pigmentosa-Linked Mutations in Transmembrane Helix 5 of Rhodopsin Disrupt Cellular Trafficking Regardless of Oligomerization State. Biochemistry 57:5188-5201
Linetsky, Mikhail; Bondelid, Karina S; Losovskiy, Sofiya et al. (2018) 4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells. Chem Res Toxicol 31:666-679
Choi, Elliot H; Suh, Susie; Sander, Christopher L et al. (2018) Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet 27:2225-2243
Zhang, Lingjun; Li, Yan; Qiu, Wen et al. (2018) Targeting CD6 for the treatment of experimental autoimmune uveitis. J Autoimmun 90:84-93
Orban, Tivadar; Leinonen, Henri; Getter, Tamar et al. (2018) A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther 364:207-220
Samanta, Amrita; Kiselar, Janna; Pumroy, Ruth A et al. (2018) Structural insights into the molecular mechanism of mouse TRPA1 activation and inhibition. J Gen Physiol 150:751-762
Saadane, Aicha; Petrov, Alexey; Mast, Natalia et al. (2018) Mechanisms that minimize retinal impact of apolipoprotein E absence. J Lipid Res 59:2368-2382
Sun, Yan; Abbondante, Serena; Karmakar, Mausita et al. (2018) Neutrophil Caspase-11 Is Required for Cleavage of Caspase-1 and Secretion of IL-1? in Aspergillus fumigatus Infection. J Immunol 201:2767-2775
Nahomi, Rooban B; Sampathkumar, Sruthi; Myers, Angela M et al. (2018) The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice. Invest Ophthalmol Vis Sci 59:2042-2053
Kiser, Philip D; Zhang, Jianye; Sharma, Aditya et al. (2018) Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol 150:571-590

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