This application requests the renewal of a Vision Core grant that supports more than 30 vision research labs with 29 qualifying NEI awards at Harvard. The overall goal of the proposed Vision Core is to enhance vision' research at Harvard by providing vision scientists with resources and facilities that could not be supported by individual laboratories. A further objective of the Vision Core is to provide a focus that promotes collaborations between vision scientists and encourages other investigators to do research on vision and the eye. The Vision, Core will support three modules that have been serving the vision research community during the current funding period. A Neural Imaging Module provides resources to facilitate experiments using a wide range of state-of-the-art imaging techniques, including in vivo two-photon microscopy, functional imaging and quantitative microscopy. A Machine Shop Module provides services for designing and manufacturing special equipment that cannot be obtained commercially. Finally, a Neuroengineering Module assists in the design and implementation of hardware and software to interface laboratory equipment for experiments. Each module is under the direction of an accomplished and capable vision scientist. Support for the Vision Core is essential for maintaining a high level of productivity in the vision community at Harvard, for fostering and supporting collaborative efforts, and for attracting new scientists to vision research.

Public Health Relevance

This core grant enhances, vision, research by providing optimal infrastructure to support the many laboratories at Harvard that study the function of the visual system in health and disease. It also provides a collaborative environment for research and for training the next generation of vision scientists. By doing so, it plays an important role n advancing the understanding and treatment of dysfunctions of the visual system.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY012196-18
Application #
8885828
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
Project Start
1998-03-01
Project End
2016-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
18
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Harvard Medical School
Department
Biology
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
Crake, Calum; Brinker, Spencer T; Coviello, Christian M et al. (2018) A dual-mode hemispherical sparse array for 3D passive acoustic mapping and skull localization within a clinical MRI guided focused ultrasound device. Phys Med Biol 63:065008
Turecek, Josef; Regehr, Wade G (2018) Synaptotagmin 7 Mediates Both Facilitation and Asynchronous Release at Granule Cell Synapses. J Neurosci 38:3240-3251
Cheadle, Lucas; Tzeng, Christopher P; Kalish, Brian T et al. (2018) Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement. Neuron 99:525-539.e10
Tao, Rongya; Wang, Caixia; Stöhr, Oliver et al. (2018) Inactivating hepatic follistatin alleviates hyperglycemia. Nat Med 24:1058-1069
Chen, Bo; Li, Yi; Yu, Bin et al. (2018) Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations. Cell 174:1599
Xu, Jie; Bartolome, Christopher L; Low, Cho Shing et al. (2018) Genetic identification of leptin neural circuits in energy and glucose homeostases. Nature 556:505-509
Martínez-François, Juan Ramón; Fernández-Agüera, María Carmen; Nathwani, Nidhi et al. (2018) BAD and KATP channels regulate neuron excitability and epileptiform activity. Elife 7:
Liu, Yuanyuan; Latremoliere, Alban; Li, Xinjian et al. (2018) Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature 561:547-550
Chen, Bo; Li, Yi; Yu, Bin et al. (2018) Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations. Cell 174:521-535.e13
Liu, Jinyue; Reggiani, Jasmine D S; Laboulaye, Mallory A et al. (2018) Tbr1 instructs laminar patterning of retinal ganglion cell dendrites. Nat Neurosci 21:659-670

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