The Center for Neural Science at New York University is a premier site for research on functional aspects of vision. Eighteen investigators from the Center request support for their vision research through continuation of a Core Grant. They are bound together by their research Interests In the neural and behavioral bases of vision and visually guided behavior. The proposed Core will comprise of four modules, each of which will benefit research in the research areas represented by program faculty: 1. A Visual Displays Module which will provide support for the development of state-of-the-art software for the generation of a wide variety of visual stimuli for psychophysical, neurophysiological, and brain experiments. 2. A Design and Fabrication Module which will provide expertise to design and build novel electronic and mechanical devices such as theose required for multielectrode recording in the visual cortex, noninvasive methods of eye movement recording, and Interface devices for behavioral and blloglcal experiments. 3. A Neuroanatomy and Molecular Biology Module which will provide expert support for the processing of neuroanatomlcal material at both the light and EM level, for the analysis and localization of electrophysiological recording sites In histological material, and for the creation of transgene-containing viruses to modify neuronal funtlon experimentally. 4. A Functional Imaging Module which will provide support for hardware and software services for users of the Siemens MRI scanner and associated devices In the Center for Brain Imaging, giving access for Core researchers to functional and structural Imaging capabilities for human and animal research.

Public Health Relevance

NEI-funded researchers at NYU study the brain mechanisms of vision, and their work will lead to greater understanding of the basis of seeing In healthy and diseased Individuals. The Core grant will provide foundational support for their work.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY013079-12
Application #
8045403
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Liberman, Ellen S
Project Start
2000-04-01
Project End
2015-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
12
Fiscal Year
2011
Total Cost
$587,716
Indirect Cost
Name
New York University
Department
Neurology
Type
Schools of Arts and Sciences
DUNS #
041968306
City
New York
State
NY
Country
United States
Zip Code
10012
Aoki, Chiye; Chen, Yi-Wen; Chowdhury, Tara Gunkali et al. (2018) ?4??-GABAA receptors in dorsal hippocampal CA1 of adolescent female rats traffic to the plasma membrane of dendritic spines following voluntary exercise and contribute to protection of animals from activity-based anorexia through localization at excitator J Neurosci Res 96:1450-1466
Chen, Yi-Wen; Actor-Engel, Hannah; Aoki, Chiye (2018) ?4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males. Mol Cell Neurosci 90:33-48
Shen, Hui; Sabaliauskas, Nicole; Yang, Lie et al. (2017) Role of ?4-containing GABAA receptors in limiting synaptic plasticity and spatial learning of female mice during the pubertal period. Brain Res 1654:116-122
Kelly, Jenna G; Hawken, Michael J (2017) Quantification of neuronal density across cortical depth using automated 3D analysis of confocal image stacks. Brain Struct Funct 222:3333-3353
Aoki, Chiye; Chowdhury, Tara G; Wable, Gauri S et al. (2017) Synaptic changes in the hippocampus of adolescent female rodents associated with resilience to anxiety and suppression of food restriction-evoked hyperactivity in an animal model for anorexia nervosa. Brain Res 1654:102-115
Nedelescu, Hermina; Chowdhury, Tara G; Wable, Gauri S et al. (2017) Cerebellar sub-divisions differ in exercise-induced plasticity of noradrenergic axons and in their association with resilience to activity-based anorexia. Brain Struct Funct 222:317-339
Chen, Yi-Wen; Actor-Engel, Hannah; Sherpa, Ang Doma et al. (2017) NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise. Brain Struct Funct 222:2271-2294
Santiago, Adrienne; Aoki, Chiye; Sullivan, Regina M (2017) From attachment to independence: Stress hormone control of ecologically relevant emergence of infants' responses to threat. Curr Opin Behav Sci 14:78-85
Pesaran, Bijan; Freedman, David J (2016) Where Are Perceptual Decisions Made in the Brain? Trends Neurosci 39:642-644
Sherpa, Ang Doma; Xiao, Fanrong; Joseph, Neethu et al. (2016) Activation of ?-adrenergic receptors in rat visual cortex expands astrocytic processes and reduces extracellular space volume. Synapse 70:307-16

Showing the most recent 10 out of 106 publications