Abstract

The OVERALL aims of this Vision Research Core (VRC) are to provide: access to resources outside the scope of individual R01 awards access to technical expertise outside the scope a single laboratory staff training to remove barriers to efficient translational research and collaboration The research areas supported by the VRC span the analysis and treatments of retinal degenerations, developmental disorders, glaucoma and other disorders, as well as and a range of cutting-edge basic science initiatives. We have implemented four resource modules that continue the natural evolution of how this research group works together, serving 15 investigators holding 21 NEI R01 awards. The Histomics Module derives from the strengths in mouse genetics at the Moran Eye Center and the high demand for tissue profiling. Almost every JMEC laboratory has need of high quality ?histomics? (cryosectioning, paratoming, genotyping, immunocytochemistry, PCR, ISH). Specifically the Histomics module provides: High-quality cryotomy resources through two professionally maintained Leica CM3050S systems Paraffin embedding and section services via a new Leica Paratome PCR and genotyping services Mouse line cryopreservation services

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY014800-12
Application #
9123600
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
12
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Nagarajan, N; Jones, B W; West, P J et al. (2018) Corticostriatal circuit defects in Hoxb8 mutant mice. Mol Psychiatry 23:1-10
Bowen, Randy C; Zhou, Andrew Xingyu; Bondalapati, Sailaja et al. (2018) Comparative analysis of the safety and efficacy of intracameral cefuroxime, moxifloxacin and vancomycin at the end of cataract surgery: a meta-analysis. Br J Ophthalmol 102:1268-1276
Loizos, Kyle; Marc, Robert; Humayun, Mark et al. (2018) Increasing Electrical Stimulation Efficacy in Degenerated Retina: Stimulus Waveform Design in a Multiscale Computational Model. IEEE Trans Neural Syst Rehabil Eng 26:1111-1120
Bahmani, Zahra; Daliri, Mohammad Reza; Merrikhi, Yaser et al. (2018) Working Memory Enhances Cortical Representations via Spatially Specific Coordination of Spike Times. Neuron 97:967-979.e6
Usher, Will; Klacansky, Pavol; Federer, Frederick et al. (2018) A Virtual Reality Visualization Tool for Neuron Tracing. IEEE Trans Vis Comput Graph 24:994-1003
Marc, Robert E; Sigulinsky, Crystal Lynn; Pfeiffer, Rebecca L et al. (2018) Heterocellular Coupling Between Amacrine Cells and Ganglion Cells. Front Neural Circuits 12:90
Choi, Rene; Gorusupudi, Aruna; Bernstein, Paul S (2018) Long-term follow-up of autosomal dominant Stargardt macular dystrophy (STGD3) subjects enrolled in a fish oil supplement interventional trial. Ophthalmic Genet 39:307-313
Hanke-Gogokhia, Christin; Frederick, Jeanne M; Zhang, Houbin et al. (2018) Binary Function of ARL3-GTP Revealed by Gene Knockouts. Adv Exp Med Biol 1074:317-325
Simmons, Aaron B; Bretz, Colin A; Wang, Haibo et al. (2018) Gene therapy knockdown of VEGFR2 in retinal endothelial cells to treat retinopathy. Angiogenesis 21:751-764
Deng, Wen-Tao; Li, Jie; Zhu, Ping et al. (2018) Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy. Mol Vis 24:17-28

Showing the most recent 10 out of 372 publications