Abstract

The OVERALL aims of this Vision Research Core (VRC) are to provide: access to resources outside the scope of individual R01 awards access to technical expertise outside the scope a single laboratory staff training to remove barriers to efficient translational research and collaboration The research areas supported by the VRC span the analysis and treatments of retinal degenerations, developmental disorders, glaucoma and other disorders, as well as and a range of cutting-edge basic science initiatives. We have implemented four resource modules that continue the natural evolution of how this research group works together, serving 15 investigators holding 21 NEI R01 awards. The Physiology Module is a powerful set of tools that VRC faculty use for animal model validation and disease profiling: ERGs, OptoMotry behavioral testing, and a range of ocular imaging tools (OCT, Mi- cron). Our new module includes in vivo / in vitro 2-photon imaging. Specifically the Physiology Module provides: Dual UTAS ERG systems (one within the JMEC vivarium) Dual OptoMotry systems within the JMEC vivarium Three Micron mouse imaging systems (one within the JMEC vivarium) An additional Micron IV mouse imaging system with image-guided ERG function Dual Spectralis OCT systems (one within the JMEC vivarium) A new Bruker Ultima 2-photon microscope Technical support for all these systems

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY014800-13
Application #
9301559
Study Section
Special Emphasis Panel (ZEY1)
Project Start
2005-07-01
Project End
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
13
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Nurminen, Lauri; Merlin, Sam; Bijanzadeh, Maryam et al. (2018) Top-down feedback controls spatial summation and response amplitude in primate visual cortex. Nat Commun 9:2281
Bretz, Colin A; Divoky, Vladimir; Prchal, Josef et al. (2018) Erythropoietin Signaling Increases Choroidal Macrophages and Cytokine Expression, and Exacerbates Choroidal Neovascularization. Sci Rep 8:2161
Arunkumar, Ranganathan; Calvo, Charles M; Conrady, Christopher D et al. (2018) What do we know about the macular pigment in AMD: the past, the present, and the future. Eye (Lond) 32:992-1004
Yarishkin, Oleg; Phuong, Tam T T; Lakk, Monika et al. (2018) TRPV4 Does Not Regulate the Distal Retinal Light Response. Adv Exp Med Biol 1074:553-560
Sauer, Lydia; Gensure, Rebekah H; Hammer, Martin et al. (2018) Fluorescence Lifetime Imaging Ophthalmoscopy: A Novel Way to Assess Macular Telangiectasia Type 2. Ophthalmol Retina 2:587-598
Becker, Silke; Wang, Haibo; Simmons, Aaron B et al. (2018) Targeted Knockdown of Overexpressed VEGFA or VEGF164 in Müller cells maintains retinal function by triggering different signaling mechanisms. Sci Rep 8:2003
Bijanzadeh, Maryam; Nurminen, Lauri; Merlin, Sam et al. (2018) Distinct Laminar Processing of Local and Global Context in Primate Primary Visual Cortex. Neuron 100:259-274.e4
Lakk, Monika; Young, Derek; Baumann, Jackson M et al. (2018) Polymodal TRPV1 and TRPV4 Sensors Colocalize but Do Not Functionally Interact in a Subpopulation of Mouse Retinal Ganglion Cells. Front Cell Neurosci 12:353
Sharif, Ali S; Yu, Dongmei; Loertscher, Stuart et al. (2018) C8ORF37 Is Required for Photoreceptor Outer Segment Disc Morphogenesis by Maintaining Outer Segment Membrane Protein Homeostasis. J Neurosci 38:3160-3176
Akbarian, Amir; Niknam, Kaiser; Parsa, Moahammadbagher et al. (2018) Developing a Nonstationary Computational Framework With Application to Modeling Dynamic Modulations in Neural Spiking Responses. IEEE Trans Biomed Eng 65:241-253

Showing the most recent 10 out of 372 publications