Abstract

The OVERALL aims of this Vision Research Core (VRC) are to provide: access to resources outside the scope of individual R01 awards access to technical expertise outside the scope a single laboratory staff training to remove barriers to efficient translational research and collaboration The research areas supported by the VRC span the analysis and treatments of retinal degenerations, developmental disorders, glaucoma and other disorders, as well as and a range of cutting-edge basic science initiatives. We have implemented four resource modules that continue the natural evolution of how this research group works together, serving 15 investigators holding 21 NEI R01 awards. The Physiology Module is a powerful set of tools that VRC faculty use for animal model validation and disease profiling: ERGs, OptoMotry behavioral testing, and a range of ocular imaging tools (OCT, Mi- cron). Our new module includes in vivo / in vitro 2-photon imaging. Specifically the Physiology Module provides: Dual UTAS ERG systems (one within the JMEC vivarium) Dual OptoMotry systems within the JMEC vivarium Three Micron mouse imaging systems (one within the JMEC vivarium) An additional Micron IV mouse imaging system with image-guided ERG function Dual Spectralis OCT systems (one within the JMEC vivarium) A new Bruker Ultima 2-photon microscope Technical support for all these systems

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY014800-13
Application #
9301559
Study Section
Special Emphasis Panel (ZEY1)
Project Start
2005-07-01
Project End
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
13
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Marc, Robert E; Sigulinsky, Crystal Lynn; Pfeiffer, Rebecca L et al. (2018) Heterocellular Coupling Between Amacrine Cells and Ganglion Cells. Front Neural Circuits 12:90
Choi, Rene; Gorusupudi, Aruna; Bernstein, Paul S (2018) Long-term follow-up of autosomal dominant Stargardt macular dystrophy (STGD3) subjects enrolled in a fish oil supplement interventional trial. Ophthalmic Genet 39:307-313
Hanke-Gogokhia, Christin; Frederick, Jeanne M; Zhang, Houbin et al. (2018) Binary Function of ARL3-GTP Revealed by Gene Knockouts. Adv Exp Med Biol 1074:317-325
Simmons, Aaron B; Bretz, Colin A; Wang, Haibo et al. (2018) Gene therapy knockdown of VEGFR2 in retinal endothelial cells to treat retinopathy. Angiogenesis 21:751-764
Deng, Wen-Tao; Li, Jie; Zhu, Ping et al. (2018) Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy. Mol Vis 24:17-28
Andersen, Karl M; Sauer, Lydia; Gensure, Rebekah H et al. (2018) Characterization of Retinitis Pigmentosa Using Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). Transl Vis Sci Technol 7:20
Yarishkin, Oleg; Phuong, Tam T T; Bretz, Colin A et al. (2018) TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells. J Gen Physiol 150:1660-1675
Elias, Eerik; Yang, Ning; Wang, Ping et al. (2018) Glutamate Activity Regulates and Dendritic Development of J-RGCs. Front Cell Neurosci 12:249
Nurminen, Lauri; Merlin, Sam; Bijanzadeh, Maryam et al. (2018) Top-down feedback controls spatial summation and response amplitude in primate visual cortex. Nat Commun 9:2281
Bretz, Colin A; Divoky, Vladimir; Prchal, Josef et al. (2018) Erythropoietin Signaling Increases Choroidal Macrophages and Cytokine Expression, and Exacerbates Choroidal Neovascularization. Sci Rep 8:2161

Showing the most recent 10 out of 372 publications