Abstract

CORE 3: ANIMAL MODELS AND ORGAN CULTURE ABSTRACT The goal of the Animal Models Core is to facilitate the use of animals and eye organ culture to study visual function and visual diseases by qualifying NEI funded researchers. We also assist non-qualifying investigators in generating preliminary data for funding. This is accomplished by providing expertise in animal models for glaucoma, retinal degeneration, ocular vascular disease, eye organ culture, and infectious diseases and includes animal handling and anesthesia. We also provide expertise and equipment necessary for the evaluation of visual function and disease including, ERG, multifocal ERG, OCT, retinal imaging, IOP and outflow facility determination. Because we are one of the only, if not the only, Vision Research Core with an associated Regional Primate Center, we are in a unique position to provide access to vision research involving non-human primates. As a result, this core has also facilitated vision research by investigators at other institutions and their papers cite this core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY016665-11
Application #
9152462
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
11
Fiscal Year
2016
Total Cost
$172,709
Indirect Cost
$59,827

  Institution

Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Farnoodian, Mitra; Sorenson, Christine M; Sheibani, Nader (2018) Negative Regulators of Angiogenesis, Ocular Vascular Homeostasis, and Pathogenesis and Treatment of Exudative AMD. J Ophthalmic Vis Res 13:470-486
Sauter, Monica M; Kolb, Aaron W; Brandt, Curtis R (2018) Toll-like receptors 4, 5, 6 and 7 are constitutively expressed in non-human primate retinal neurons. J Neuroimmunol 322:26-35
Aboualizadeh, Ebrahim; Sorenson, Christine M; Schofield, Alex J et al. (2018) Temporal diabetes-induced biochemical changes in distinctive layers of mouse retina. Sci Rep 8:1096
Lewin, Andrew C; Kolb, Aaron W; McLellan, Gillian J et al. (2018) Genomic, Recombinational and Phylogenetic Characterization of Global Feline Herpesvirus 1 Isolates. Virology 518:385-397
Saghiri, Mohammad Ali; Asatourian, Armen; Nguyen, Eric H et al. (2018) Hydrogel Arrays and Choroidal Neovascularization Models for Evaluation of Angiogenic Activity of Vital Pulp Therapy Biomaterials. J Endod 44:773-779
Melgar-Asensio, Ignacio; Kandela, Irawati; Aird, Fraser et al. (2018) Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging. Invest Ophthalmol Vis Sci 59:4071-4081
Ghanian, Zahra; Mehrvar, Shima; Jamali, Nasim et al. (2018) Time-lapse microscopy of oxidative stress demonstrates metabolic sensitivity of retinal pericytes under high glucose condition. J Biophotonics 11:e201700289
Rouhimoghadam, Milad; Safarian, Shahrokh; Carroll, Jason S et al. (2018) Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing. Front Physiol 9:907
Telle, Mary R; Chen, Nickolas; Shinsako, Daniel et al. (2018) Relationship between corneal sensitivity, corneal thickness, corneal diameter, and intraocular pressure in normal cats and cats with congenital glaucoma. Vet Ophthalmol :
Schmitt, Heather M; Schlamp, Cassandra L; Nickells, Robert W (2018) Targeting HDAC3 Activity with RGFP966 Protects Against Retinal Ganglion Cell Nuclear Atrophy and Apoptosis After Optic Nerve Injury. J Ocul Pharmacol Ther 34:260-273

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