ADMINISTRATIVE ARRANGEMENTS Principal Investigator: Linda M. Zangwill. PhD Dr. Linda Zangwill has the necessary leadership and management skills and experience to serve as PI of the UCSD NEI Vision Research Core. As Co-Director of Clinical Research, and as Director of the Imaging Data Evaluation and Analysis (IDEA) Reading Center, she has been responsible for development and expansion of the clinical research enterprise at the Hamilton Glaucoma Center. Dr. Zangwill has had continuous ROI funding since 1995 for the Diagnostic Innovations in Glaucoma Study (DIGS): Structural Assessment, which has led to significant improvements in our ability to 1) detect glaucomatous structural damage and change, 2) understand the complex relationship between optic disc damage and visual field loss, 3) measure the rate of structural change, 4) predict who will develop progressive visual field loss. In addition, as PI for the NEI funded African Descent and Glaucoma Evaluation Study (ADAGES), OHTS and EGPS: Glaucoma detection using Confocal Scanning Laser Ophthalmoscopy and co-Investigator for the CSLO Ancillary Study to the OHTS, Dr. Zangwill has proven leadership and management skills coordinating large national and international multi-center studies, working with collaborating investigators to set priorities, and meet deadlines while maintaining an extremely productive collaborative research program. Moreover, she has been responsible for the development of an integrated data management system that provides (on a secure shared server), reading center reviewed structural, functional, clinical and demographic data acquired from the DIGS and ADAGES to collaborating researchers for analysis. This data management system required the coordination between her computer group (3 FTEs), Reading Center staff (4 FTEs) and clinical research staff (4 staff) as well as collaborating clinical researchers (at UCSD and elsewhere) and statisticians. As PI for the UCSD Vision Research Core she will bring her management expertise to work with module directors and the Advisory committee to implement a transparent decision-making process, to establish realistic expectations with clear timelines and to ensure timely response to investigator and staff concerns.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
1P30EY022589-01
Application #
8434368
Study Section
Special Emphasis Panel (ZEY1-VSN (10))
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
1
Fiscal Year
2012
Total Cost
$31,001
Indirect Cost
$11,001
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Muftuoglu, Ilkay Kilic; Gaber, Raouf; Bartsch, Dirk-Uwe et al. (2018) Comparison of conventional color fundus photography and multicolor imaging in choroidal or retinal lesions. Graefes Arch Clin Exp Ophthalmol 256:643-649
Branham, Kari; Guru, Aditya A; Kozak, Igor et al. (2018) Identification of Novel Deletions as the Underlying Cause of Retinal Degeneration in Two Pedigrees. Adv Exp Med Biol 1074:229-236
Christopher, Mark; Belghith, Akram; Weinreb, Robert N et al. (2018) Retinal Nerve Fiber Layer Features Identified by Unsupervised Machine Learning on Optical Coherence Tomography Scans Predict Glaucoma Progression. Invest Ophthalmol Vis Sci 59:2748-2756
Kroeger, Heike; Grimsey, Neil; Paxman, Ryan et al. (2018) The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Sci Signal 11:
You, Qi Sheng; Gaber, Raouf; Meshi, Amit et al. (2018) HIGH-DOSE HIGH-FREQUENCY AFLIBERCEPT FOR RECALCITRANT NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retina 38:1156-1165
Christopher, Mark; Belghith, Akram; Bowd, Christopher et al. (2018) Performance of Deep Learning Architectures and Transfer Learning for Detecting Glaucomatous Optic Neuropathy in Fundus Photographs. Sci Rep 8:16685
Ju, Won-Kyu; Shim, Myoung Sup; Kim, Keun-Young et al. (2018) Ubiquinol promotes retinal ganglion cell survival and blocks the apoptotic pathway in ischemic retinal degeneration. Biochem Biophys Res Commun 503:2639-2645
Bowd, Christopher; Zangwill, Linda M; Weinreb, Robert N et al. (2018) Racial Differences in Rate of Change of Spectral-Domain Optical Coherence Tomography-Measured Minimum Rim Width and Retinal Nerve Fiber Layer Thickness. Am J Ophthalmol 196:154-164
Hou, Huiyuan; Moghimi, Sasan; Zangwill, Linda M et al. (2018) Inter-eye Asymmetry of Optical Coherence Tomography Angiography Vessel Density in Bilateral Glaucoma, Glaucoma Suspect, and Healthy Eyes. Am J Ophthalmol 190:69-77
Chekuri, Anil; Guru, Aditya A; Biswas, Pooja et al. (2018) IFT88 mutations identified in individuals with non-syndromic recessive retinal degeneration result in abnormal ciliogenesis. Hum Genet 137:447-458

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