OVERVIEW The Animal Structure and Function Module will provide new centralized space for state-of-the-art structural and functional animal testing with a dedicated animal care technician to conduct the testing and to train investigators and their staff on the use of the new equipment. The recent growth in the number of faculty in the Department of Ophthalmology conducting animal structure and functional testing has grown rapidly in recent years. With this critical mass of investigators, there are compelling financial and logistical reasons to minimize the number of animals in scientific studies. The use of ocular imaging methods that enable longitudinal observations in a living animal can greatly reduce the need to sacrifice animals at different time points in an experiment. In addition, the high cost of retinal imaging devices has made it prohibitively expensive to duplicate retinal imaging equipment. This core module provides a range of imaging and functioning testing services and with the purchase of a Micron III Animal Imaging System with mfERG and ERG setup and a spectral domain optical coherence tomography instrument housed in a new centralized laboratory, allow our researchers to make most efficient use of their time and resources. Moreover, it will leverage the engineering, computing and imaging expertise of several core laboratories (e.g. Drs. Weinreb, Silva, Bartsch and Zhang) and the international reputation of the UCSD Jacobs School of Engineering and National Center for Microsocpy and Imaging Research and Department of Bioengineering (of which Dr. Bartsch is affiliated). In summary, the Animal Structure and Function Module will provide a streamlined set of tools that many faculty use on an as-needed basis for animal model validation and disease model profiling: OCT, FA, ICG, HRA, multi-focal ERG testing, and a range of ocular imaging services. This module is led by Drs. Zhang and Bartsch, whose in vivo imaging and functional analysis expertise and knowledge are invaluable assets.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
1P30EY022589-01
Application #
8434376
Study Section
Special Emphasis Panel (ZEY1-VSN (10))
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
1
Fiscal Year
2012
Total Cost
$167,629
Indirect Cost
$42,474
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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Villanueva, Adda; Biswas, Pooja; Kishaba, Kameron et al. (2018) Identification of the genetic determinants responsible for retinal degeneration in families of Mexican descent. Ophthalmic Genet 39:73-79
Murata, Hiroshi; Zangwill, Linda M; Fujino, Yuri et al. (2018) Validating Variational Bayes Linear Regression Method With Multi-Central Datasets. Invest Ophthalmol Vis Sci 59:1897-1904
Shim, Myoung Sup; Kim, Keun-Young; Bu, Jung Hyun et al. (2018) Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. Cell Death Dis 9:285
Manalastas, Patricia I C; Zangwill, Linda M; Daga, Fabio B et al. (2018) The Association Between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect, and Healthy Eyes. J Glaucoma 27:227-232
Muftuoglu, Ilkay Kilic; Ramkumar, Hema L; Bartsch, Dirk-Uwe et al. (2018) QUANTITATIVE ANALYSIS OF THE INNER RETINAL LAYER THICKNESSES IN AGE-RELATED MACULAR DEGENERATION USING CORRECTED OPTICAL COHERENCE TOMOGRAPHY SEGMENTATION. Retina 38:1478-1484
Kabbara, Sami W; Zangwill, Linda M; Mundae, Rusdeep et al. (2018) Comparing optical coherence tomography radial and cube scan patterns for measuring Bruch's membrane opening minimum rim width (BMO-MRW) in glaucoma and healthy eyes: cross-sectional and longitudinal analysis. Br J Ophthalmol 102:344-351
Biswas, Pooja; Naeem, Muhammad Asif; Ali, Muhammad Hassaan et al. (2018) Whole-Exome Sequencing Identifies Novel Variants that Co-segregates with Autosomal Recessive Retinal Degeneration in a Pakistani Pedigree. Adv Exp Med Biol 1074:219-228

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