ADMINISTRATIVE ARRANGEMENTS Principal Investigator: Linda M. Zangwill. PhD Dr. Linda Zangwill has the necessary leadership and management skills and experience to serve as PI of the UCSD NEI Vision Research Core. As Co-Director of Clinical Research, and as Director of the Imaging Data Evaluation and Analysis (IDEA) Reading Center, she has been responsible for development and expansion of the clinical research enterprise at the Hamilton Glaucoma Center. Dr. Zangwill has had continuous ROI funding since 1995 for the Diagnostic Innovations in Glaucoma Study (DIGS): Structural Assessment, which has led to significant improvements in our ability to 1) detect glaucomatous structural damage and change, 2) understand the complex relationship between optic disc damage and visual field loss, 3) measure the rate of structural change, 4) predict who will develop progressive visual field loss. In addition, as PI for the NEI funded African Descent and Glaucoma Evaluation Study (ADAGES), OHTS and EGPS: Glaucoma detection using Confocal Scanning Laser Ophthalmoscopy and co-Investigator for the CSLO Ancillary Study to the OHTS, Dr. Zangwill has proven leadership and management skills coordinating large national and international multi-center studies, working with collaborating investigators to set priorities, and meet deadlines while maintaining an extremely productive collaborative research program. Moreover, she has been responsible for the development of an integrated data management system that provides (on a secure shared server), reading center reviewed structural, functional, clinical and demographic data acquired from the DIGS and ADAGES to collaborating researchers for analysis. This data management system required the coordination between her computer group (3 FTEs), Reading Center staff (4 FTEs) and clinical research staff (4 staff) as well as collaborating clinical researchers (at UCSD and elsewhere) and statisticians. As PI for the UCSD Vision Research Core she will bring her management expertise to work with module directors and the Advisory committee to implement a transparent decision-making process, to establish realistic expectations with clear timelines and to ensure timely response to investigator and staff concerns.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
4P30EY022589-05
Application #
9087262
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
5
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Muftuoglu, Ilkay Kilic; Alam, Mostafa; You, Qi Sheng et al. (2018) LONG-TERM REMISSION OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION WITH AS-NEEDED ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY. Retina 38:516-522
Bosse, Brandon; Damle, Samir; Akinin, Abraham et al. (2018) In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode-Based Retinal Prosthesis. Invest Ophthalmol Vis Sci 59:5885-5892
Mundae, Rusdeep S; Zangwill, Linda M; Kabbara, Sami W et al. (2018) A Longitudinal Analysis of Peripapillary Choroidal Thinning in Healthy and Glaucoma Subjects. Am J Ophthalmol 186:89-95
Wu, Zhichao; Medeiros, Felipe A; Weinreb, Robert N et al. (2018) Performance of the 10-2 and 24-2 Visual Field Tests for Detecting Central Visual Field Abnormalities in Glaucoma. Am J Ophthalmol 196:10-17
Manalastas, Patricia Isabel C; Belghith, Akram; Weinreb, Robert N et al. (2018) Automated Beta Zone Parapapillary Area Measurement to Differentiate Between Healthy and Glaucoma Eyes. Am J Ophthalmol 191:140-148
Shim, Myoung Sup; Kim, Keun-Young; Noh, Mark et al. (2018) Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line. Biochem Biophys Res Commun 503:2690-2697
Galvao, Joana; Iwao, Keiichiro; Apara, Akintomide et al. (2018) The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration. Invest Ophthalmol Vis Sci 59:2736-2747
Xu, Benjamin Y; Penteado, Rafaella C; Weinreb, Robert N (2018) Diurnal Variation of Optical Coherence Tomography Measurements of Static and Dynamic Anterior Segment Parameters. J Glaucoma 27:16-21
Meshi, Amit; Chen, Kevin C; You, Qi Sheng et al. (2018) ANATOMICAL AND FUNCTIONAL TESTING IN DIABETIC PATIENTS WITHOUT RETINOPATHY: Results of Optical Coherence Tomography Angiography and Visual Acuity Under Varying Contrast and Luminance Conditions. Retina :
Suh, Min Hee; Zangwill, Linda M; Manalastas, Patricia Isabel C et al. (2018) Deep-Layer Microvasculature Dropout by Optical Coherence Tomography Angiography and Microstructure of Parapapillary Atrophy. Invest Ophthalmol Vis Sci 59:1995-2004

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