Abstract

Functional Vision Module The Functional Vision Module will provide the technologies required to interrogate visual function in experimental animals to the investigators involved in this P30 Core Grant for Vision Research. This module will provide state of the art assessment of visual function in mice and zebrafish. Included are visual electrophysiological assays such as the electroretinogram (ERG) and the visual evoked potential (VEP); and visual behavior assays such as the pupillary light reflex (PLR), the optokinetic reflex (OKR), optomotor reflex (OMR) and threshold measurement. Collectively, these assays interrogate visual function from light detection in the photoreceptors to signal integration and interpretation within the brain. Access to this core module will support NEI R01 funded investigators, help newly recruited investigators obtain data for NEI R01 grant submissions, foster collaborative interactions between RO1 funded investigators and newly recruited investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY025585-05
Application #
10003325
Study Section
Special Emphasis Panel (ZEY1)
Project Start
2016-09-01
Project End
2021-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
5
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195

  Publications

Dhingra, Anuradha; Bell, Brent A; Peachey, Neal S et al. (2018) Microtubule-Associated Protein 1 Light Chain 3B, (LC3B) Is Necessary to Maintain Lipid-Mediated Homeostasis in the Retinal Pigment Epithelium. Front Cell Neurosci 12:351
Swarup, Aditi; Bell, Brent A; Du, Jianhai et al. (2018) Deletion of GLUT1 in mouse lens epithelium leads to cataract formation. Exp Eye Res 172:45-53
Medeiros, Carla S; Marino, Gustavo K; Santhiago, Marcony R et al. (2018) The Corneal Basement Membranes and Stromal Fibrosis. Invest Ophthalmol Vis Sci 59:4044-4053
Yu, Minzhong; Yan, Weiming; Beight, Craig (2018) Lutein and Zeaxanthin Isomers Protect against Light-Induced Retinopathy via Decreasing Oxidative and Endoplasmic Reticulum Stress in BALB/cJ Mice. Nutrients 10:
Bell, Brent A; Bonilha, Vera L; Samuels, Ivy S (2018) A Novel Approach for Integrating AF-SLO and SDOCT Imaging Data Demonstrates the Ability to Identify Early Retinal Abnormalities in Mutant Mice and Evaluate the Effects of Genetic and Pharmacological Manipulation. Adv Exp Med Biol 1074:167-173
Dupps Jr, William J (2018) Corneal crosslinking: Stabilization or rehabilitation? J Cataract Refract Surg 44:525-527
Choi, Elliot H; Suh, Susie; Sander, Christopher L et al. (2018) Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet 27:2225-2243
Zhang, Lingjun; Li, Yan; Qiu, Wen et al. (2018) Targeting CD6 for the treatment of experimental autoimmune uveitis. J Autoimmun 90:84-93
Orban, Tivadar; Leinonen, Henri; Getter, Tamar et al. (2018) A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther 364:207-220
Zhao, Yue; Chundury, Rao V; Blandford, Alexander D et al. (2018) Anatomical Description of Zygomatic Foramina in African American Skulls. Ophthalmic Plast Reconstr Surg 34:168-171

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