The Administrative Core of the Phase 111 COBRE application seeks to offer scientific oversight, leadership, and centralized administrative services for the University of South Carolina's biomedical research community by providing central core facilities to researchers across departments and colleges, as well as to the greater research community statewide. The Core's centralized administrative services and research core management generates significant efficiencies for both staffing and operations for all its core facilities and affiliated investigators. The Core's administrative services include: fiscal management of affiliated accounts, day-to-day operations, expert pre-award assistance (including budget development and proposal assembly and submission), and post-award grants administration to all affiliated faculty. This Core has expanded its services to include community engagement and resource development, along with being active in the recruitment of new CCCR members, facilitating intra-institutional collaborations, and organizing the CCCR's annual meeting. The Administrative Core continually evaluates its services through the ongoing consultation and evaluation by the Internal Steering Committee, the Director/PI, and the External Advisory Committee. To carry out these efforts, this Core will carry out the following aims during Phase 111: Provide central management of grant administration services, coordination of community engagement initiatives and resource development efforts. The Core provides centralized services and has developed infrastructure that fully optimizes grant administration, community engagement, and resource development services on behalf of the Center's core facilities and member investigators. Provide scientific leadership, organizational management, and ongoing evaluation of the Research Cores. It is the responsibility of the Core to provide continued research training and financial support to investigators to best facilitate their proposed research, along with implementing new research technology and overseeing the training of investigators who utilize the Center-supported cores.
Colorectal cancer is diagnosed in over 140,000 Americans each year, and takes 51,000 lives. There is need for focused research on this disease in order to identify and implement improved strategies for diagnosing, preventing, and treating it. The Administrative Core facilitates better coordination and savings within core facility use to promote the goals of the Center for Colon Cancer Research at the University of South Carolina.
|Liang, Jiaxin; Chen, Mengqian; Hughes, Daniel et al. (2018) CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases. Cancer Res 78:6594-6606|
|Liu, Shou; Lee, Ji Shin; Jie, Chunfa et al. (2018) HER2 Overexpression Triggers an IL1? Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance. Cancer Res 78:2040-2051|
|Wyatt, Michael D; Reilly, Nicole M; Patel, Shikha et al. (2018) Thiopurine-induced mitotic catastrophe in Rad51d-deficient mammalian cells. Environ Mol Mutagen 59:38-48|
|Liu, Changlong; Banister, Carolyn E; Weige, Charles C et al. (2018) PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids. Proc Natl Acad Sci U S A 115:E5066-E5075|
|Kaur, Kamaljeet; Saxena, Arpit; Debnath, Irina et al. (2018) Antibiotic-mediated bacteriome depletion in ApcMin/+ mice is associated with reduction in mucus-producing goblet cells and increased colorectal cancer progression. Cancer Med 7:2003-2012|
|Eberth, Jan M; Thibault, Annie; Caldwell, Renay et al. (2018) A statewide program providing colorectal cancer screening to the uninsured of South Carolina. Cancer 124:1912-1920|
|Peña, Edsel A; Wu, Wensong; Piegorsch, Walter et al. (2017) Model Selection and Estimation with Quantal-Response Data in Benchmark Risk Assessment. Risk Anal 37:716-732|
|Abdalla, Aya; Atcherley, Christopher W; Pathirathna, Pavithra et al. (2017) In Vivo Ambient Serotonin Measurements at Carbon-Fiber Microelectrodes. Anal Chem 89:9703-9711|
|Farmaki, Elena; Kaza, Vimala; Papavassiliou, Athanasios G et al. (2017) Induction of the MCP chemokine cluster cascade in the periphery by cancer cell-derived Ccl3. Cancer Lett 389:49-58|
|Brown, Jacob L; Rosa-Caldwell, Megan E; Lee, David E et al. (2017) Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice. J Cachexia Sarcopenia Muscle 8:926-938|
Showing the most recent 10 out of 51 publications