The Vascular and Cardiac Function Core will provide services and training for COBRE and LSUHSC investigators who will use animal models of cardiovascular disease and/or in vivo technology to answer specific aims outlined in their projects.
The specific aims of this Core are: 1. To provide skilled personnel to assist and/or perform highly specialized surgical and technical procedures involving ultrasound imaging, radio telemetric recording of blood pressure, use of pressure-volume conductance catheters to assess cardiac structure and function, sympathetic nerve recording, microinjection procedures, vascular injury, cardiac ischemia and blood flow, and assessment of renal function;2. To assist in producing models of hypertension, ischemia/reperfusion injury, vascular injury, atherosclerosis, diabetes, cerebral ischemia, acute kidney injury, volume overload and drug-induced cardiac damage from which tissues will be collected for histological, biochemical, genetic and/or proteomic analysis;3. To conduct experiments and assist COBRE and LSUHSC investigators with the collection and interpretation of physiological data;4. To educate investigators regarding potential uses of The Vascular and Cardiac Function Core resources to enhance their research objectives and provide avenues towards developing translational research projects. Investigators will have access to the core facilities to complete experimental protocols on their own or with the aid and supervision of the Core's technical staff. The core will also provide services for the design and development of new animal models for cardiovascular research. The services ofthe Core encompass;1) ultrasound imaging, 2) measurement of blood pressure, heart rate, spontaneous baroreflex, and core body temperature by radio telemetry, 3) tail cuff analysis of blood pressure and heart rate, 4) cardiac left ventricular pressure-volume analysis, 5) CNS microinjection, 6) microdialysis, 7) nerve recording, 8) tissue collection, 9) blood flow analysis, 10) blood chemistry, and 11) assessment ofthe renal excretion of water and electrolytes. The state-of-the-art technology and experienced personnel provided by this Core will enhance the COBRE and University investigators progress towards acquisition of extramural funding.

Public Health Relevance

With the exponentially increasing number of mouse and rat models of disease there is a dire need for reliable and flexible cardiovascular phenotyping cores. Investigators from diverse disciplines often lack the training necessary to determine the cardiovascular phenotype of mouse and rat models and rely more and more on core expertise to do so.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZGM1-TWD-C (C3))
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Louisiana State Univ Hsc New Orleans
New Orleans
United States
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Xu, Jiaxi; Sriramula, Srinivas; Lazartigues, Eric (2018) Excessive Glutamate Stimulation Impairs ACE2 Activity Through ADAM17-Mediated Shedding in Cultured Cortical Neurons. Cell Mol Neurobiol :
Flanagan, M; Li, C; Dietrich, M A et al. (2018) Downregulation of heat shock protein B8 decreases osteogenic differentiation potential of dental pulp stem cells during in vitro proliferation. Cell Prolif 51:e12420
Yue, Xinping; Basting, Tyler M; Flanagan, Thomas W et al. (2018) Nicotine Downregulates the Compensatory Angiotensin-Converting Enzyme 2/Angiotensin Type 2 Receptor of the Renin-Angiotensin System. Ann Am Thorac Soc 15:S126-S127
Mukerjee, Snigdha; Zhu, Yun; Zsombok, Andrea et al. (2018) Perinatal Exposure to Western Diet Programs Autonomic Dysfunction in the Male Offspring. Cell Mol Neurobiol 38:233-242
Washington, Shannan D; Musarrat, Farhana; Ertel, Monica K et al. (2018) CTCF Binding Sites in the Herpes Simplex Virus 1 Genome Display Site-Specific CTCF Occupation, Protein Recruitment, and Insulator Function. J Virol 92:
Poret, J M; Souza-Smith, F; Marcell, S J et al. (2018) High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats. Int J Obes (Lond) 42:535-541
Todaro, Dustin R; Augustus-Wallace, Allison C; Klein, Jennifer M et al. (2018) Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly. J Biol Chem 293:18192-18206
Basting, Tyler; Xu, Jiaxi; Mukerjee, Snigdha et al. (2018) Glutamatergic neurons of the paraventricular nucleus are critical contributors to the development of neurogenic hypertension. J Physiol 596:6235-6248
Washington, Shannan D; Edenfield, Samantha I; Lieux, Caroline et al. (2018) Depletion of the insulator protein CTCF results in HSV-1 reactivation in vivo. J Virol :
Lammi, Matthew R; Saketkoo, Lesley Ann; Gordon, Jessica K et al. (2018) Changes in hemodynamic classification over time are common in systemic sclerosis-associated pulmonary hypertension: insights from the PHAROS cohort. Pulm Circ 8:2045893218757404

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