Abstract

The Nuclear Magnetic Resonance (NMR) Core with the existing state-of-the-art instrumentation and techniques is represents a critical part of COBRE to address the following needs of COBRE research programs across the campus ofthe University of Delaware (1) to facilitate the research and development of NMR spectroscopy as a premier method for structural analysis of a wide variety of systems in solution and solid states, and (2) to provide support for structural analyses of small-molecule and macromolecule-based biomaterials in solution and solid states.

Public Health Relevance

Structural characterization of biomaterials at atomic resolution is critical to the design and optimization of biomaterials. Nuclear Magnetic Resonance (NMR) spectroscopy plays a unique and an irreplaceable role as a method for atomic-scale structural analysis ofvarious kinds of materials. The NMR Core will provide stateof- the-art NMR research instrumentation and expertise to help COBRE investigators gain fundamental insights into the structures of materials under investigation. These studies will ultimately generate materials systems that are optimized for their targeted drug delivery and tissue engineering applications.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM110758-01
Application #
8735398
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C3))
Project Start
Project End
Budget Start
2014-09-30
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$352,808
Indirect Cost
$126,649

  Institution

Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716

  Publications

Wu, Pengcheng; Yap, Glenn P A; Theopold, Klaus H (2018) Structure and Reactivity of Chromium(VI) Alkylidenes. J Am Chem Soc 140:7088-7091
Fritz, Matthew; Quinn, Caitlin M; Wang, Mingzhang et al. (2018) Determination of accurate backbone chemical shift tensors in microcrystalline proteins by integrating MAS NMR and QM/MM. Phys Chem Chem Phys 20:9543-9553
Gupta, Rupal; Stringer, John; Struppe, Jochem et al. (2018) Direct detection and characterization of bioinorganic peroxo moieties in a vanadium complex by 17O solid-state NMR and density functional theory. Solid State Nucl Magn Reson 91:15-20
Liu, Jun; Chen, Qingqing; Rozovsky, Sharon (2018) Selenocysteine-Mediated Expressed Protein Ligation of SELENOM. Methods Mol Biol 1661:265-283
O'Brien, Jessica G K; Chintala, Srinivasa R; Fox, Joseph M (2018) Stereoselective Synthesis of Bicyclo[6.1.0]nonene Precursors of the Bioorthogonal Reagents s-TCO and BCN. J Org Chem 83:7500-7503
Burch, Jason M; Mashayekh, Siavash; Wykoff, Dennis D et al. (2018) Bacterial Derived Carbohydrates Bind Cyr1 and Trigger Hyphal Growth in Candida albicans. ACS Infect Dis 4:53-58
Guan, Weiye; Liao, Jennie; Watson, Mary P (2018) Vinylation of Benzylic Amines via C-N Bond Functionalization of Benzylic Pyridinium Salts. Synthesis (Stuttg) 50:3231-3237
McDonald, Nathan D; DeMeester, Kristen E; Lewis, Amanda L et al. (2018) Structural and functional characterization of a modified legionaminic acid involved in glycosylation of a bacterial lipopolysaccharide. J Biol Chem 293:19113-19126
Haider, Michael J; Zhang, Huixi Violet; Sinha, Nairiti et al. (2018) Self-assembly and soluble aggregate behavior of computationally designed coiled-coil peptide bundles. Soft Matter 14:5488-5496
Hadden, Jodi A; Perilla, Juan R (2018) Molecular Dynamics Simulations of Protein-Drug Complexes: A Computational Protocol for Investigating the Interactions of Small-Molecule Therapeutics with Biological Targets and Biosensors. Methods Mol Biol 1762:245-270

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