Abstract

The Mass Spectrometry and Surface Characterization (MSSC) Core is a critical component of COBRE serving the diverse needs of researchers for mass spectrometric and surface characterization of biomaterials. In COBRE 111, the MSSC Core will (1) expand the scope of its instrumentation and scientific capabilities to include analysis of high-molecular weight samples;(2) upgrade and replace the current mass spectrometry instrumentation to maximize the impact of the core for COBRE research;(3) continue to provide support for structural analyses of small-molecule and polymer-based biomaterials.

Public Health Relevance

The ability to develop advanced biomaterials with customized control over morphological, mechanical and biological properties will lead to significant advancement in biomedical fields. The MSSC Core will provide mass spectrometry and surface characterization capabilities needed for the COBRE-based research. These capabilities will enable COBRE investigators to gain comprehensive understanding of the structure of the designed biomaterials and precursors, the knowledge critical to their ability to design biomaterials optimized for their intended biological applications.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM110758-01
Application #
8735399
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C3))
Project Start
Project End
Budget Start
2014-09-30
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$140,400
Indirect Cost
$50,400

  Institution

Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716

  Publications

Wu, Pengcheng; Yap, Glenn P A; Theopold, Klaus H (2018) Structure and Reactivity of Chromium(VI) Alkylidenes. J Am Chem Soc 140:7088-7091
Fritz, Matthew; Quinn, Caitlin M; Wang, Mingzhang et al. (2018) Determination of accurate backbone chemical shift tensors in microcrystalline proteins by integrating MAS NMR and QM/MM. Phys Chem Chem Phys 20:9543-9553
Gupta, Rupal; Stringer, John; Struppe, Jochem et al. (2018) Direct detection and characterization of bioinorganic peroxo moieties in a vanadium complex by 17O solid-state NMR and density functional theory. Solid State Nucl Magn Reson 91:15-20
Liu, Jun; Chen, Qingqing; Rozovsky, Sharon (2018) Selenocysteine-Mediated Expressed Protein Ligation of SELENOM. Methods Mol Biol 1661:265-283
O'Brien, Jessica G K; Chintala, Srinivasa R; Fox, Joseph M (2018) Stereoselective Synthesis of Bicyclo[6.1.0]nonene Precursors of the Bioorthogonal Reagents s-TCO and BCN. J Org Chem 83:7500-7503
Burch, Jason M; Mashayekh, Siavash; Wykoff, Dennis D et al. (2018) Bacterial Derived Carbohydrates Bind Cyr1 and Trigger Hyphal Growth in Candida albicans. ACS Infect Dis 4:53-58
Guan, Weiye; Liao, Jennie; Watson, Mary P (2018) Vinylation of Benzylic Amines via C-N Bond Functionalization of Benzylic Pyridinium Salts. Synthesis (Stuttg) 50:3231-3237
McDonald, Nathan D; DeMeester, Kristen E; Lewis, Amanda L et al. (2018) Structural and functional characterization of a modified legionaminic acid involved in glycosylation of a bacterial lipopolysaccharide. J Biol Chem 293:19113-19126
Haider, Michael J; Zhang, Huixi Violet; Sinha, Nairiti et al. (2018) Self-assembly and soluble aggregate behavior of computationally designed coiled-coil peptide bundles. Soft Matter 14:5488-5496
Hadden, Jodi A; Perilla, Juan R (2018) Molecular Dynamics Simulations of Protein-Drug Complexes: A Computational Protocol for Investigating the Interactions of Small-Molecule Therapeutics with Biological Targets and Biosensors. Methods Mol Biol 1762:245-270

Showing the most recent 10 out of 177 publications