The Administrative Core (Core A) will continue to be directed by Bharat Ramratnam, M.D. Dr. Ramratnam assumed the role of PI of the COBRE Center for Cancer Research and Development in the end of 2011 upon the retirement of founding PI Douglas Hixson, Ph.D. The major goal of the Core is to provide administrative oversight to all activities of the Phase III COBRE. The following specific aims will be pursued:
(Aim 1) To maintain an organizational structure that ensures effective communication between the supervisory, administrative and service oriented components of the COBRE.
(Aim 2) To devise strategies to increase the use of the Proteomics and Molecular Pathology Cores during Phase III and assist users by providing designated bioinformatics expertise.
(Aim 3) To provide an overview of the Administrative Core?s establishment of benchmarks for evaluating core performance on financial, scientific and managerial grounds.
(Aim 4) To describe new policies/initiatives established by the Administrative Core regarding fee waiver or reduction through a Junior Investigator Support Award (JISP) that is limited to non-R01 funded faculty at the Assistant Professor level conducting cancer research.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM110759-01A1
Application #
8882664
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C3))
Project Start
Project End
Budget Start
2015-05-01
Budget End
2016-04-30
Support Year
1
Fiscal Year
2015
Total Cost
$260,386
Indirect Cost
$93,087
Name
Rhode Island Hospital
Department
Type
DUNS #
075710996
City
Providence
State
RI
Country
United States
Zip Code
02903
Chorzalska, Anna; Ahsan, Nagib; Rao, R Shyama Prasad et al. (2018) Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK-ERK and NF-?B pathways in a model of chronic myeloid leukemia. Mol Oncol 12:630-647
Patel, Mohak; Leggett, Susan E; Landauer, Alexander K et al. (2018) Rapid, topology-based particle tracking for high-resolution measurements of large complex 3D motion fields. Sci Rep 8:5581
Lo, Wan-Lin; Shah, Neel H; Ahsan, Nagib et al. (2018) Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT. Nat Immunol 19:733-741
Ghanekar, Alok; Xiao, Gang; Zheng, Yi (2017) High Contrast Far-Field Radiative Thermal Diode. Sci Rep 7:6339
Leggett, Susan E; Khoo, Amanda S; Wong, Ian Y (2017) Multicellular tumor invasion and plasticity in biomimetic materials. Biomater Sci 5:1460-1479
Jamwal, Rohitash; Topletz, Ariel R; Ramratnam, Bharat et al. (2017) Ultra-high performance liquid chromatography tandem mass-spectrometry for simple and simultaneous quantification of cannabinoids. J Chromatogr B Analyt Technol Biomed Life Sci 1048:10-18
Leggett, Susan E; Wong, Ian Y (2017) Nanomedicine: Catching tumour cells in the zone. Nat Nanotechnol 12:191-193
Wood, Stephanie M; Gill, Anthony J; Brodsky, Alexander S et al. (2017) Fatty acid-binding protein 1 is preferentially lost in microsatellite instable colorectal carcinomas and is immune modulated via the interferon ? pathway. Mod Pathol 30:123-133
Valentin, Thomas M; Leggett, Susan E; Chen, Po-Yen et al. (2017) Stereolithographic printing of ionically-crosslinked alginate hydrogels for degradable biomaterials and microfluidics. Lab Chip 17:3474-3488
Ahsan, Nagib; Belmont, Judson; Chen, Zhuo et al. (2017) Highly reproducible improved label-free quantitative analysis of cellular phosphoproteome by optimization of LC-MS/MS gradient and analytical column construction. J Proteomics 165:69-74

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