Abstract

A major purpose of a Phase III COBRE Center is to provide a program for identifying and supporting scientifically worthy pilot projects that will utilize existing COBRE Core Labs and generate preliminary results in support of new research grant proposals and applications. The COBRE-PSF Pilot Project Program will continue a successful program of supporting Pilot Projects by advertising competitions for pilot project awards broadly across the four participating institutions, obtaining external reviews of all applications, and consulting with our EAC to identify new projects to support. The Pilot Project Program will interact with other components of the Administrative Core to provide, overall, 1) mentoring and career-development support for COBRE junior faculty by experienced senior faculty researchers, 2) a program for the overall enhancement of writing skills and especially for the writing of high-quality research publications and strongly competitive grant applications based on the results of pilot projects supported by COBRE, and 3) monitoring of scientific progress and career development of mentored COBRE researchers. Individual COBRE Pilot Projects will, by definition, interact strongly with one or more of our three COBRE Core Labs.

Public Health Relevance

This component of our application provides a program for recruiting and evaluating small pilot project grants in the area of protein structure and function. In some cases the results will support enlarging the study through regular NIH grant mechanisms.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM110761-01
Application #
8735423
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C3))
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$225,000
Indirect Cost
$75,000

  Institution

Name
University of Kansas Lawrence
Department
Type
DUNS #
076248616
City
Lawrence
State
KS
Country
United States
Zip Code
66045

  Publications

Garabedian, Alyssa; Baird, Matthew A; Porter, Jacob et al. (2018) Linear and Differential Ion Mobility Separations of Middle-Down Proteoforms. Anal Chem 90:2918-2925
Barta, Michael L; Tachiyama, Shoichi; Muthuramalingam, Meenakumari et al. (2018) Using disruptive insertional mutagenesis to identify the in situ structure-function landscape of the Shigella translocator protein IpaB. Protein Sci 27:1392-1406
Kyrychenko, Alexander; Lim, Nathan M; Vasquez-Montes, Victor et al. (2018) Refining Protein Penetration into the Lipid Bilayer Using Fluorescence Quenching and Molecular Dynamics Simulations: The Case of Diphtheria Toxin Translocation Domain. J Membr Biol 251:379-391
Damalanka, Vishnu C; Kim, Yunjeong; Galasiti Kankanamalage, Anushka C et al. (2018) Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease. Eur J Med Chem 143:881-890
Arnett, David C; Bailey, Sheila K; Johnson, Carey K (2018) Exploring the conformations of nitric oxide synthase with fluorescence. Front Biosci (Landmark Ed) 23:2133-2145
Galasiti Kankanamalage, Anushka C; Kim, Yunjeong; Damalanka, Vishnu C et al. (2018) Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element. Eur J Med Chem 150:334-346
Lan, Lan; Liu, Hao; Smith, Amber R et al. (2018) Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins. BMC Cancer 18:809
Wu, Long; Zhang, Xin; Zhao, Liqin (2018) Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention. J Neurosci 38:6665-6681
Haimov, Ora; Sehrawat, Urmila; Tamarkin-Ben Harush, Ana et al. (2018) Dynamic interactions of eIF4G1 with eIF4E and eIF1 underlie scanning dependent and independent translation. Mol Cell Biol :
Herrera, Alvaro I; Ploscariu, Nicoleta T; Geisbrecht, Brian V et al. (2018) 1H, 15N, and 13C resonance assignments of the third domain from the S. aureus innate immune evasion protein Eap. Biomol NMR Assign 12:175-178

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