This COBRE has a neariy decade history of successfully idenfifying and supporting Pilot Projects which have lead to additional funding and scienfific success for our recipients. In many ways of all the positives that have fiowed from our COBRE, the success of our pilot programs is probably one of the best examples. We have used our Pilot Projects during Phase II to in many cases introduce young senior post docs or young faculty to genefics. Often their focus was in other arenas but they were chosen as they needed access to the resources our COBRE can provide. These attempts at attracfing new invesfigators to our Center have paid off as many are now fully integrated into genefic projects as their main focus. Oklahoma confinues to have many outstanding junior investigators with novel project ideas, which are ripe for minimal investments with large potenfial returns. Two years ago, with just one e-mail announcement in the middle of summer, we had responses within two weeks for 14 potenfial pilot projects, 12 from junior COBRE-eligible investigators with 10 of these never having previously received COBRE funds. Most of these projects proposed to use the Genomics or the Quanfitative Analysis Core in this applicafion. To build on the prior success of our COBRE Pilot Projects Core has the following specific aims: 1) identify and fund highly innovative, COBRE Pilot Projects from junior COBRE invesfigators or established invesfigators with novel ideas in a new field of invesfigafion and 2) evaluate progress of projects and effectiveness of mentors and ensure that this Pilot Project program confinues to provide key resources for outstanding scientific opportunifies. We anficipate that the mechanism we have laid out in the Pilot Project Core for identifying tialent, evaluafing progress and cultivating indepence will result in continued successful faculty independence and Nafional funding success.
The current funding environment makes it difficult for new scienfists to fully develop their ideas to the point where they can compete for coveted nafional funding. The COBRE Pilot Project Core will assist up and coming new invesfigators with funding support to allow them to more fully develop their best scientific ideas and compete for nafional funding streams.
|Pelikan, Richard C; Kelly, Jennifer A; Fu, Yao et al. (2018) Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks. Nat Commun 9:2905|
|Patel, Zubin; Lu, Xiaoming; Miller, Daniel et al. (2018) A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. Hum Mol Genet :|
|Fu, Yao; Tessneer, Kandice L; Li, Chuang et al. (2018) From association to mechanism in complex disease genetics: the role of the 3D genome. Arthritis Res Ther 20:216|
|Bagavant, Harini; Dunkleberger, Micah L; Wolska, Nina et al. (2018) Antibodies to periodontogenic bacteria are associated with higher disease activity in lupus patients. Clin Exp Rheumatol :|
|Wang, Chih-Chuan; Ortiz-González, Xilma R; Yum, Sabrina W et al. (2018) ?IV Spectrinopathies Cause Profound Intellectual Disability, Congenital Hypotonia, and Motor Axonal Neuropathy. Am J Hum Genet 102:1158-1168|
|Leehan, Kerry M; Pezant, Nathan P; Rasmussen, Astrid et al. (2018) Minor salivary gland fibrosis in Sjögren's syndrome is elevated, associated with focus score and not solely a consequence of aging. Clin Exp Rheumatol 36 Suppl 112:80-88|
|Celada, Lindsay J; Kropski, Jonathan A; Herazo-Maya, Jose D et al. (2018) PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-?1 production. Sci Transl Med 10:|
|Bernatsky, Sasha; Velásquez García, Héctor A; Spinelli, John J et al. (2017) Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. Lupus Sci Med 4:e000187|
|Langefeld, Carl D; Ainsworth, Hannah C; Cunninghame Graham, Deborah S et al. (2017) Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun 8:16021|
|Aberle, Teresa; Bourn, Rebecka L; Chen, Hua et al. (2017) Use of SLICC criteria in a large, diverse lupus registry enables SLE classification of a subset of ACR-designated subjects with incomplete lupus. Lupus Sci Med 4:e000176|
Showing the most recent 10 out of 32 publications