Established in 2003, the Pacific Center for Emerging Infectious Diseases Research, a translational science center of excellence supported by funding from the Centers of Biomedical Research Excellence (COBRE) component of the Institutional Development Award (IDeA) program, seeks to develop and deploy rapid diagnostics, improved therapeutics and affordable vaccines for new, emerging and re-emerging infectious diseases that disproportionately affect underserved communities in the Asia-Pacific region. The COBRE Center also seeks to increase the diversity of the biomedical research workforce by training and mentoring native Hawaiians and other underrepresented Pacific Islanders. Thus, the Center's mission is thoroughly consistent with that of the National Institute of General Medical Sciences, which is to support basic research that lays the foundation for advances in disease diagnosis, treatment and prevention, and to increase the diversity of the research workforce by supporting the training of the next generation of scientists (www.nigms.nih.gov/About/Pages/default.aspx). The principal objective of the Phase III COBRE for emerging infectious diseases is to enhance the conditions that accelerate the pace of scientific discovery, heighten research productivity and increase competitiveness for extramural funding. The objective will be achieved by (1) enhancing the growth and sustainability of the COBRE cores in biocontainment, bioinformatics, and molecular and cellular immunology, which are grounded in the triad of customized and collaborative service, research and development, and education and training; and (2) developing and implementing a COBRE Small Grants Program, without borders, that fosters collaborations and partnerships, promotes data and resource sharing, and provides additional opportunities for mentoring and specialized training across IDeA-funded centers in research aimed at improving human health. COBRE funding during Phases I and II has transformed the landscape for mentoring and training future generations of investigators and has provided state-of-the-art core resources for multi-disciplinary collaborative research on epidemic infectious diseases. At the institutional level, COBRE funding has spurred significant commitments to recruit and retain a new cadre of productive faculty, and such efforts will continue into Phase III. High-level upper-administrative institutional commitments will ensure the sustainability of the Center and its cores beyond the Phase III COBRE period.

Public Health Relevance

To reduce human suffering from epidemic infectious diseases that disproportionately affect underserved communities in the Asia-Pacific region, the Pacific Center for Emerging Infectious Diseases Research will seek to develop rapid diagnostic tests, improved treatments and affordable vaccines. The Center will also seek to increase the diversity of the biomedical research workforce by training and mentoring native Hawaiians and other underrepresented Pacific Islanders. These goals are consistent with the mission of the National Institute of General Medical Sciences, of the National Institutes of Health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM114737-05
Application #
9735367
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Caldwell, Sheila
Project Start
2015-07-01
Project End
2021-06-30
Budget Start
2019-07-01
Budget End
2021-06-30
Support Year
5
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Hawaii
Department
Pediatrics
Type
Schools of Medicine
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Fang, Rui; Zhu, Yong; Khadka, Vedbar S et al. (2018) The Evaluation of Serum Biomarkers for Non-small Cell Lung Cancer (NSCLC) Diagnosis. Front Physiol 9:1710
Strange, Daniel P; Green, Richard; Siemann, David N et al. (2018) Immunoprofiles of human Sertoli cells infected with Zika virus reveals unique insights into host-pathogen crosstalk. Sci Rep 8:8702
Lloyd, Yukie M; Esemu, Livo F; Antallan, Jovikka et al. (2018) PCR-based detection of Plasmodium falciparum in saliva using mitochondrial cox3 and varATS primers. Trop Med Health 46:22
Seale, Lucia A; Ha, Herena Y; Hashimoto, Ann C et al. (2018) Relationship between selenoprotein P and selenocysteine lyase: Insights into selenium metabolism. Free Radic Biol Med 127:182-189
Phokrai, Phornpun; Karoonboonyanan, Wisansanee; Thanapattarapairoj, Nida et al. (2018) A Rapid Immunochromatography Test Based on Hcp1 Is a Potential Point-of-Care Test for Serological Diagnosis of Melioidosis. J Clin Microbiol 56:
Tsai, Wen-Yang; Youn, Han Ha; Tyson, Jasmine et al. (2018) Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections. Emerg Infect Dis 24:1355-1359
Chen, Tianlu; You, Yijun; Xie, Guoxiang et al. (2018) Strategy for an Association Study of the Intestinal Microbiome and Brain Metabolome Across the Lifespan of Rats. Anal Chem 90:2475-2483
Dou, Yuhong; Zhu, Yong; Ai, Junmei et al. (2018) Plasma small ncRNA pair panels as novel biomarkers for early-stage lung adenocarcinoma screening. BMC Genomics 19:545
To, Albert; Medina, Liana O; Mfuh, Kenji O et al. (2018) Recombinant Zika Virus Subunits Are Immunogenic and Efficacious in Mice. mSphere 3:
Medina, Liana O; To, Albert; Lieberman, Michael M et al. (2018) A Recombinant Subunit Based Zika Virus Vaccine Is Efficacious in Non-human Primates. Front Immunol 9:2464

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