Abstract

The Administrative Core oversees and guides the operation of the COBRE on Mechanisms of Liver Injury and Diseases at the University of Kansas Medical Center. The Program Director/Principal Investigator will be Dr. Hartmut Jaeschke, who was the PD/PI during Phase II. He will be assisted and advised by the Program Coordinator Dr. Bruno Hagenbuch and other members of the Steering Committee consisting of the chairs of the 2 cores, the Pilot Grants Program Director, and the Senior Associate Dean for Research of the School of Medicine. An External Advisory Board comprised of five internationally recognized authorities in liver research will also provide guidance and advice for the COBRE operation and will function as external reviewers for the Pilot Grants Program. The Administrative Core will oversee and guide the highly successful Core Laboratories and the Pilot Grants Program in addition to providing continued mentoring and career development guidance for junior faculty.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM118247-01
Application #
9073978
Study Section
Special Emphasis Panel (ZGM1-RCB-3 (C3))
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
1
Fiscal Year
2016
Total Cost
$279,624
Indirect Cost
$96,863

  Institution

Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160

  Publications

Jaeschke, Hartmut; Ramachandran, Anup (2018) Oxidant Stress and Lipid Peroxidation in Acetaminophen Hepatotoxicity. React Oxyg Species (Apex) 5:145-158
Willebrords, Joost; Maes, Michaël; Pereira, Isabel Veloso Alves et al. (2018) Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. Biochim Biophys Acta Mol Basis Dis 1864:819-830
Williams, Jessica A; Ding, Wen-Xing (2018) Mechanisms, pathophysiological roles and methods for analyzing mitophagy - recent insights. Biol Chem 399:147-178
Qian, Hui; Chao, Xiaojuan; Ding, Wen-Xing (2018) A PINK1-mediated mitophagy pathway decides the fate of tumors-to be benign or malignant? Autophagy 14:563-566
Chao, Xiaojuan; Wang, Shaogui; Zhao, Katrina et al. (2018) Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice. Gastroenterology 155:865-879.e12
Chao, Xiaojuan; Wang, Hua; Jaeschke, Hartmut et al. (2018) Role and mechanisms of autophagy in acetaminophen-induced liver injury. Liver Int 38:1363-1374
Woolbright, Benjamin L; Jaeschke, Hartmut (2018) Alcoholic Hepatitis: Lost in Translation. J Clin Transl Hepatol 6:89-96
Ramachandran, Anup; Duan, Luqi; Akakpo, Jephte Y et al. (2018) Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives. J Clin Transl Res 4:
Borude, Prachi; Bhushan, Bharat; Gunewardena, Sumedha et al. (2018) Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose. Am J Pathol 188:1406-1418
Singh, Rakesh K; van Haandel, Leon; Heruth, Daniel P et al. (2018) Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP. J Pharmacol Exp Ther 365:96-106

Showing the most recent 10 out of 65 publications