This program-project application is for the renewal of a center grant to facilitate, expand and strengthen programs of research and research training at the Rose F. Kennedy Center. This Center was established as a major step in the realization of an organized, multidisciplinary research and research training program in mental retardation and related aspects of human development. The major organizational feature of this program is its successful emphasis on interdisciplinary and multidisciplinary investigations. Such collaborative efforts among Kennedy Center investigators with divergent scientific backgrounds have resulted in the development of several new projects which have as their central objective the definition of fundamental morphophysiological and neurobehavioral correlations associated with the genesis of mental retardation. Biochemical and morphologic studies are defining severe degenerative disorders associated with mental retardation. Cytogenic, biochemical genetics and development physiologic studies are also being made. The basic premise in this program is that the acquisition of information concerning the normal and abnormal development of progressively more complex hierarchies of organization and the application of this knowledge to human development constitutes an approach that is immediately relevant to the problems of the cause and management of mental retardation.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD001799-22
Application #
3102697
Study Section
Mental Retardation Research and Training Committee (HDMR)
Project Start
1977-09-01
Project End
1987-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
22
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Qureshi, Irfan A; Mehler, Mark F (2014) Epigenetic mechanisms underlying the pathogenesis of neurogenetic diseases. Neurotherapeutics 11:708-20
Qureshi, Irfan A; Mehler, Mark F (2014) Epigenetics of sleep and chronobiology. Curr Neurol Neurosci Rep 14:432
Qureshi, Irfan A; Mehler, Mark F (2014) An evolving view of epigenetic complexity in the brain. Philos Trans R Soc Lond B Biol Sci 369:
Qureshi, Irfan A; Mehler, Mark F (2014) Sex, epilepsy, and epigenetics. Neurobiol Dis 72 Pt B:210-6
Nguyen, Giang D; Gokhan, Solen; Molero, Aldrin E et al. (2014) The role of H1 linker histone subtypes in preserving the fidelity of elaboration of mesendodermal and neuroectodermal lineages during embryonic development. PLoS One 9:e96858
Qureshi, Irfan A; Mehler, Mark F (2013) Epigenetic mechanisms governing the process of neurodegeneration. Mol Aspects Med 34:875-82
Qureshi, Irfan A; Mehler, Mark F (2012) Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease. Nat Rev Neurosci 13:528-41
Nalavadi, Vijayalaxmi C; Muddashetty, Ravi S; Gross, Christina et al. (2012) Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation. J Neurosci 32:2582-7
Qureshi, Irfan A; Mehler, Mark F (2011) Non-coding RNA networks underlying cognitive disorders across the lifespan. Trends Mol Med 17:337-46
Qureshi, Irfan A; Mehler, Mark F (2011) Alu transcription: a rheostat for stem cell aging? Cell Cycle 10:3820-1

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