The Rose F. Kennedy Center conducts basic and clinical research on the normal and aberrant development of the nervous system and on factors that influence human development. The clinical facilities of the Center, in addition to their role in research programs, provide services for infants and children with developmental disabilities. Several research and clinical training programs are based in the Center. The staff is multidisciplinary representing eight basic science and clinical departments within the Albert Einstein College of Medicine. Basic research programs of the Center focus upon the biological factors that influence the development and organization of the central nervous system, especially the development of neurons and their connections, receptor sites and neurotransmitters. Research on diseases that affect the brain include studies of immune mechanisms and demyelinating disorders, of the genetically determined lysosomal storage disorders and on the impact of toxic agents on the nervous system. The neurological and behavioral aspects of normal and aberrant human development are under intensive study. The emergence of visual and auditory processing capacities, intermodal sensory integration and of language in both normal and high risk infant populations are being investigated, employing both behavioral and sophisticated electrophysiological techniques. The interaction of biological and social factors on cognitive and emotional development is of particular interest. Epidemiological and social aspects of developmental disorders are also a major concern of Center investigators. The impact of perinatal factors, including nutrition, prematurity and neonatal care on neurobehavioral development is under longitudinal study. The clinical and clinical research facilities include a regional genetic counselling program, the low birth weight follow-up and evaluation (LIFE) program, and the Children's Evaluation and Rehabilitation Center (CERC). The CERC also provides the base for the Kennedy Center's University Affiliated Program.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD001799-25
Application #
3102699
Study Section
Mental Retardation Research and Training Committee (HDMR)
Project Start
1977-09-01
Project End
1990-07-31
Budget Start
1989-09-01
Budget End
1990-07-31
Support Year
25
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Qureshi, Irfan A; Mehler, Mark F (2014) Epigenetic mechanisms underlying the pathogenesis of neurogenetic diseases. Neurotherapeutics 11:708-20
Qureshi, Irfan A; Mehler, Mark F (2014) Epigenetics of sleep and chronobiology. Curr Neurol Neurosci Rep 14:432
Qureshi, Irfan A; Mehler, Mark F (2014) An evolving view of epigenetic complexity in the brain. Philos Trans R Soc Lond B Biol Sci 369:
Qureshi, Irfan A; Mehler, Mark F (2014) Sex, epilepsy, and epigenetics. Neurobiol Dis 72 Pt B:210-6
Nguyen, Giang D; Gokhan, Solen; Molero, Aldrin E et al. (2014) The role of H1 linker histone subtypes in preserving the fidelity of elaboration of mesendodermal and neuroectodermal lineages during embryonic development. PLoS One 9:e96858
Qureshi, Irfan A; Mehler, Mark F (2013) Epigenetic mechanisms governing the process of neurodegeneration. Mol Aspects Med 34:875-82
Qureshi, Irfan A; Mehler, Mark F (2012) Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease. Nat Rev Neurosci 13:528-41
Nalavadi, Vijayalaxmi C; Muddashetty, Ravi S; Gross, Christina et al. (2012) Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation. J Neurosci 32:2582-7
Qureshi, Irfan A; Mehler, Mark F (2011) Non-coding RNA networks underlying cognitive disorders across the lifespan. Trends Mol Med 17:337-46
Qureshi, Irfan A; Mehler, Mark F (2011) Alu transcription: a rheostat for stem cell aging? Cell Cycle 10:3820-1

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