description) The Rose F. Kennedy Center for Research in Mental Retardation and Developmental Disabilities is commencing its 36th year as the Center for Excellence in basic and clinical research involving the nervous system and the treatment of disabilities in children. The Center was founded on the principal that the strength of the overall research program is dependent on the excellence of individual investigators, on their ability to develop and maintain collaborative programs, and on the continued effort to translate findings from basic science into clinical applications and ultimately therapeutic interventions. The Center currently supports more than 53 individual NIH-funded research projects as well as several program projects and training grants involving 56 faculty from seven departments at the Albert Einstein College of Medicine. Research programs are focussed in five main areas: 1) normal and abnormal neural development; 2) chemical and electrical coupling of neurons; 3) systems and cognitive neuroscience; 4) neurobehavioral assessment of development; and 5) pathobiology of developmental and degenerative disorders. Clinical facilities include the Children's Evaluation and Rehabilitation Center (CERC), which treats more than 9,000 children and their families from the largely under-served populations of the Bronx. At the heart of the Kennedy Center are nine core facilities to support research and clinical activities. Over its history, the Center has been directed by a series of directors C each of whom has further developed and refined the research mission of the Center. Dr. Donald Faber assumed the directorship of the Center in November of 1999. Dr. Joseph Arezzo continues as the Associate Director. During the current funding period, a number of changes have occurred within the Center, including changes in Center investigators, core services, as well as focus (to some degree) of the Center. The number of funding projects being supported by Center facilities, the dollar amount of these studies, and the number of research scientists has, for the most part, remained fairly stable.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
2P30HD001799-36
Application #
6132643
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Hanson, James W
Project Start
1977-09-01
Project End
2005-06-30
Budget Start
2000-08-15
Budget End
2001-06-30
Support Year
36
Fiscal Year
2000
Total Cost
$1,192,724
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Qureshi, Irfan A; Mehler, Mark F (2014) Epigenetic mechanisms underlying the pathogenesis of neurogenetic diseases. Neurotherapeutics 11:708-20
Qureshi, Irfan A; Mehler, Mark F (2014) Epigenetics of sleep and chronobiology. Curr Neurol Neurosci Rep 14:432
Qureshi, Irfan A; Mehler, Mark F (2014) An evolving view of epigenetic complexity in the brain. Philos Trans R Soc Lond B Biol Sci 369:
Qureshi, Irfan A; Mehler, Mark F (2014) Sex, epilepsy, and epigenetics. Neurobiol Dis 72 Pt B:210-6
Nguyen, Giang D; Gokhan, Solen; Molero, Aldrin E et al. (2014) The role of H1 linker histone subtypes in preserving the fidelity of elaboration of mesendodermal and neuroectodermal lineages during embryonic development. PLoS One 9:e96858
Qureshi, Irfan A; Mehler, Mark F (2013) Epigenetic mechanisms governing the process of neurodegeneration. Mol Aspects Med 34:875-82
Nalavadi, Vijayalaxmi C; Muddashetty, Ravi S; Gross, Christina et al. (2012) Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation. J Neurosci 32:2582-7
Qureshi, Irfan A; Mehler, Mark F (2012) Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease. Nat Rev Neurosci 13:528-41
Qureshi, Irfan A; Mehler, Mark F (2011) Non-coding RNA networks underlying cognitive disorders across the lifespan. Trends Mol Med 17:337-46
Qureshi, Irfan A; Mehler, Mark F (2011) Alu transcription: a rheostat for stem cell aging? Cell Cycle 10:3820-1

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