This application requests continued core support in the areas of administration and common support activities for the Child Development and Mental Retardation Center of the University of Washington. The mission of the Center is to conduct a coordinated, broad-based, multidisciplinary program of research and training in the area of mental retardation and related aspects of human development. The broad goals of the Center are: 1) to work toward the prevention of mental retardation and related problems of human development; 2) to improve the quality of life for mentally retarded and similarly handicapped children; 3) to help insure that adequate numbers of specialists are available to conduct research, train specialists, and deliver services necessary to prevent mental retardation and improve the quality of life for mentally retarded and handicapped children; and 4) to develop exemplary professional services which can be demonstrated in training and research programs for mentally retarded and similarly handicapped children. Specific research goals include contributing to the further understanding of mental retardation by expanding scientific knowledge of biological and behavioral development; and translating research findings promptly into better programs for the prevention, diagnosis, treatment, and habilitation of mentally retarded and similarly handicapped children.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
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Mental Retardation Research and Training Committee (HDMR)
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University of Washington
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Shelton, Annie L; Wang, Jun Y; Fourie, Emily et al. (2018) Middle Cerebellar Peduncle Width-A Novel MRI Biomarker for FXTAS? Front Neurosci 12:379
Peeples, Eric S; Ezeokeke, Chikodinaka K; Juul, Sandra E et al. (2018) Evaluating a Targeted Bedside Measure of Cerebral Perfusion in a Nonhuman Primate Model of Neonatal Hypoxic-Ischemic Encephalopathy. J Ultrasound Med 37:913-920
Mitchell, Timothy; MacDonald, James W; Srinouanpranchanh, Sengkeo et al. (2018) Evidence of cardiac involvement in the fetal inflammatory response syndrome: disruption of gene networks programming cardiac development in nonhuman primates. Am J Obstet Gynecol 218:438.e1-438.e16
Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867
Klusek, Jessica; Porter, Anna; Abbeduto, Leonard et al. (2018) Curvilinear Association Between Language Disfluency and FMR1 CGG Repeat Size Across the Normal, Intermediate, and Premutation Range. Front Genet 9:344
Shickman, Ryan; Famula, Jessica; Tassone, Flora et al. (2018) Age- and CGG repeat-related slowing of manual movement in fragile X carriers: A prodrome of fragile X-associated tremor ataxia syndrome? Mov Disord 33:628-636
Boland, Michael J; Nazor, Kristopher L; Tran, Ha T et al. (2017) Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome. Brain 140:582-598
Choi, Won-Seok; Kim, Hyung-Wook; Tronche, Fran├žois et al. (2017) Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson's disease-like non-motor symptoms without loss of dopamine neurons. Sci Rep 7:44989
Zhou, Vanessa; Munson, Jeffrey A; Greenson, Jessica et al. (2017) An exploratory longitudinal study of social and language outcomes in children with autism in bilingual home environments. Autism :1362361317743251
Klusek, Jessica; LaFauci, Giuseppe; Adayev, Tatyana et al. (2017) Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety. J Neurodev Disord 9:16

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