Abstract

The university of Washington's Mental Retardation Research Center (MRRC), based at the Child Development and Mental Retardation Center (CDMRC), provides a comprehensive interdisciplinary research program in the field of mental retardation/developmental disabilities and related aspects of human development. The overall goals of the CDMRC are to prevent mental retardation and related problems of human development and to improve the quality of life for individuals with developmental disabilities. To help accomplish this, research is carried out in six major areas: (1) Teratology, (2) Developmental and Molecular Genetics, (3) Perinatal Biology, (4) Developmental Neuroscience, (5) Developmental Processes, and (6) Biomedical and Behavioral Outcome and Intervention. Through this grant application, support is requested for five scientific core facilities and one administrative core to enhance the effectiveness of the approximately 150 scientists carrying our their activities within the six MRRC research programs. The scientific core support facilities are as follows: (1) Genetics, (2) Neuroscience, (3) Instrument Development Laboratory, (4) Infant Primate Research Laboratory, and (5) Media Services. Other MRRC objectives include training researchers in various disciplines, disseminating research findings, and maintaining linkages to clinical training activities and exemplary service programs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD002274-30
Application #
2402990
Study Section
Mental Retardation Research Committee (HDMR)
Project Start
1989-08-01
Project End
1999-07-31
Budget Start
1997-08-01
Budget End
1998-07-31
Support Year
30
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Pediatrics
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Klusek, Jessica; Porter, Anna; Abbeduto, Leonard et al. (2018) Curvilinear Association Between Language Disfluency and FMR1 CGG Repeat Size Across the Normal, Intermediate, and Premutation Range. Front Genet 9:344
Shickman, Ryan; Famula, Jessica; Tassone, Flora et al. (2018) Age- and CGG repeat-related slowing of manual movement in fragile X carriers: A prodrome of fragile X-associated tremor ataxia syndrome? Mov Disord 33:628-636
Shelton, Annie L; Wang, Jun Y; Fourie, Emily et al. (2018) Middle Cerebellar Peduncle Width-A Novel MRI Biomarker for FXTAS? Front Neurosci 12:379
Peeples, Eric S; Ezeokeke, Chikodinaka K; Juul, Sandra E et al. (2018) Evaluating a Targeted Bedside Measure of Cerebral Perfusion in a Nonhuman Primate Model of Neonatal Hypoxic-Ischemic Encephalopathy. J Ultrasound Med 37:913-920
Mitchell, Timothy; MacDonald, James W; Srinouanpranchanh, Sengkeo et al. (2018) Evidence of cardiac involvement in the fetal inflammatory response syndrome: disruption of gene networks programming cardiac development in nonhuman primates. Am J Obstet Gynecol 218:438.e1-438.e16
Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867
Zhou, Vanessa; Munson, Jeffrey A; Greenson, Jessica et al. (2017) An exploratory longitudinal study of social and language outcomes in children with autism in bilingual home environments. Autism :1362361317743251
Klusek, Jessica; LaFauci, Giuseppe; Adayev, Tatyana et al. (2017) Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety. J Neurodev Disord 9:16
Boland, Michael J; Nazor, Kristopher L; Tran, Ha T et al. (2017) Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome. Brain 140:582-598
Choi, Won-Seok; Kim, Hyung-Wook; Tronche, François et al. (2017) Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson's disease-like non-motor symptoms without loss of dopamine neurons. Sci Rep 7:44989

Showing the most recent 10 out of 276 publications