The Brain Imaging Core supports IDDRC Research Affiliates conducfing in vivo brain imaging research in humans and animals using a variety of modalities that include structural and functional Magnefic Resonance (MR) brain imaging, MR spectroscopy, evoked response potentials (ERP), and PET, and provides a wide range of sophisticated image processing support. The Core is organized into four highly interrelated components: (1) technical support and development;(2) image analysis;(3) human electrophyslology;and (4) in vivo animal imaging. All components of the Core are organized to inform affiliates of the advantages (and pitfalls) of useful technologies and to provide expert technical guidance for both invesfigators inexperienced in imaging techniques as well as experienced neuroscienfists. To maximize resources in this highly complex field, the Brain Imaging Core operates in collaboration with the MR Research laboratory and the Integrated Brain Imaging Center (IBIC) which are part of the Department of Radiology. The MR Research Laboratory emphasizes MR imaging hardware and development of specialized techniques and equipment. IBIC emphasizes study design and image analysis. It should also be noted that in the previous compefitive renewal. Brain Imaging and Cellular Morphology were core components of a larger Neuroscience Core. In this application, primarily as a result of expansions and developments in both core components, each now funcfions as a separate core. However, substanfial interrelafionships remain, with the newly developed animal imaging services bridging both components.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
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Special Emphasis Panel (ZHD1-MRG-C (16))
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University of Washington
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Shelton, Annie L; Wang, Jun Y; Fourie, Emily et al. (2018) Middle Cerebellar Peduncle Width-A Novel MRI Biomarker for FXTAS? Front Neurosci 12:379
Peeples, Eric S; Ezeokeke, Chikodinaka K; Juul, Sandra E et al. (2018) Evaluating a Targeted Bedside Measure of Cerebral Perfusion in a Nonhuman Primate Model of Neonatal Hypoxic-Ischemic Encephalopathy. J Ultrasound Med 37:913-920
Mitchell, Timothy; MacDonald, James W; Srinouanpranchanh, Sengkeo et al. (2018) Evidence of cardiac involvement in the fetal inflammatory response syndrome: disruption of gene networks programming cardiac development in nonhuman primates. Am J Obstet Gynecol 218:438.e1-438.e16
Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867
Klusek, Jessica; Porter, Anna; Abbeduto, Leonard et al. (2018) Curvilinear Association Between Language Disfluency and FMR1 CGG Repeat Size Across the Normal, Intermediate, and Premutation Range. Front Genet 9:344
Shickman, Ryan; Famula, Jessica; Tassone, Flora et al. (2018) Age- and CGG repeat-related slowing of manual movement in fragile X carriers: A prodrome of fragile X-associated tremor ataxia syndrome? Mov Disord 33:628-636
Zhou, Vanessa; Munson, Jeffrey A; Greenson, Jessica et al. (2017) An exploratory longitudinal study of social and language outcomes in children with autism in bilingual home environments. Autism :1362361317743251
Klusek, Jessica; LaFauci, Giuseppe; Adayev, Tatyana et al. (2017) Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety. J Neurodev Disord 9:16
Boland, Michael J; Nazor, Kristopher L; Tran, Ha T et al. (2017) Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome. Brain 140:582-598
Choi, Won-Seok; Kim, Hyung-Wook; Tronche, Fran├žois et al. (2017) Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson's disease-like non-motor symptoms without loss of dopamine neurons. Sci Rep 7:44989

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